The molecular basis of tight nuclear tethering and inactivation of cGAS.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
26
05
2020
accepted:
12
08
2020
pubmed:
11
9
2020
medline:
12
11
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Nucleic acids derived from pathogens induce potent innate immune responses
Identifiants
pubmed: 32911481
doi: 10.1038/s41586-020-2749-z
pii: 10.1038/s41586-020-2749-z
pmc: PMC7704945
mid: NIHMS1620035
doi:
Substances chimiques
Nucleosomes
0
DNA
9007-49-2
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, human
EC 2.7.7.-
cGAS protein, mouse
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-677Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145287
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121584
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127575
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148153
Pays : United States
Références
Wu, J. & Chen, Z. J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32, 461–488 (2014).
doi: 10.1146/annurev-immunol-032713-120156
Hopfner, K. P. & Hornung, V. Molecular mechanisms and cellular functions of cGAS–STING signalling. Nat. Rev. Mol. Cell Biol. 21, 501–521 (2020).
doi: 10.1038/s41580-020-0244-x
Roers, A., Hiller, B. & Hornung, V. Recognition of endogenous nucleic acids by the innate immune system. Immunity 44, 739–754 (2016).
doi: 10.1016/j.immuni.2016.04.002
Kato, H., Takahasi, K. & Fujita, T. RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol. Rev. 243, 91–98 (2011).
doi: 10.1111/j.1600-065X.2011.01052.x
Paludan, S. R. & Bowie, A. G. Immune sensing of DNA. Immunity 38, 870–880 (2013).
doi: 10.1016/j.immuni.2013.05.004
Ablasser, A. & Chen, Z. J. cGAS in action: Expanding roles in immunity and inflammation. Science 363, eaat8657 (2019).
doi: 10.1126/science.aat8657
Burdette, D. L. & Vance, R. E. STING and the innate immune response to nucleic acids in the cytosol. Nat. Immunol. 14, 19–26 (2013).
doi: 10.1038/ni.2491
Barber, G. N. Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr. Opin. Immunol. 23, 10–20 (2011).
doi: 10.1016/j.coi.2010.12.015
Ablasser, A. et al. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380–384 (2013).
doi: 10.1038/nature12306
Gao, P. et al. Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153, 1094–1107 (2013).
doi: 10.1016/j.cell.2013.04.046
Zhao, B. et al. A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature 569, 718–722 (2019).
doi: 10.1038/s41586-019-1228-x
Stetson, D. B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93–103 (2006).
doi: 10.1016/j.immuni.2005.12.003
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786–791 (2013).
doi: 10.1126/science.1232458
Volkman, H. E., Cambier, S., Gray, E. E. & Stetson, D. B. Tight nuclear tethering of cGAS is essential for preventing autoreactivity. eLife 8, e47491 (2019).
doi: 10.7554/eLife.47491
Zierhut, C. et al. The cytoplasmic DNA sensor cGAS promotes mitotic cell death. Cell 178, 302–315 (2019).
doi: 10.1016/j.cell.2019.05.035
Jiang, H. et al. Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. EMBO J. 38, e102718 (2019).
doi: 10.15252/embj.2019102718
Gentili, M. et al. The N-terminal domain of cGAS determines preferential association with centromeric DNA and innate immune activation in the nucleus. Cell Rep. 26, 2377–2393 (2019).
doi: 10.1016/j.celrep.2019.01.105
Liu, H. et al. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563, 131–136 (2018).
doi: 10.1038/s41586-018-0629-6
Li, X. et al. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 39, 1019–1031 (2013).
doi: 10.1016/j.immuni.2013.10.019
Wang, W. W., Zeng, Y., Wu, B., Deiters, A. & Liu, W. R. A chemical biology approach to reveal Sirt6-targeted histone H3 sites in nucleosomes. ACS Chem. Biol. 11, 1973–1981 (2016).
doi: 10.1021/acschembio.6b00243
Tachiwana, H. et al. Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T. Proc. Natl Acad. Sci. USA 107, 10454–10459 (2010).
doi: 10.1073/pnas.1003064107
Liebschner, D. et al. Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix. Acta Crystallogr. D 75, 861–877 (2019).
doi: 10.1107/S2059798319011471
Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D 66, 486–501 (2010).
doi: 10.1107/S0907444910007493