Changed Profile of Serum Transferrin Isoforms in Primary Biliary Cholangitis.
capillary electrophoresis
glycosylation
primary biliary cholangitis
transferrin isoforms
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
08 Sep 2020
08 Sep 2020
Historique:
received:
06
08
2020
revised:
19
08
2020
accepted:
01
09
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
12
9
2020
Statut:
epublish
Résumé
Liver damage affects the synthesis of proteins and glycoproteins, and alters their posttranslational modification, such as glycosylation changing the serum profile of glycoprotein isoforms. The retention of hydrophobic bile acids in the course of cholestatic liver diseases is a major cause of liver damage in primary biliary cholangitis (PBC). The study objective was to determine the serum profile of transferrin isoforms in primary biliary cholangitis and compare it to transferrin isoforms profile in extrahepatic cholestasis. The study was carried out in 76 patients with PBC and 40 healthy blood donors. Transferrin isoforms were analyzed by the capillary electrophoresis method. The mean relative concentrations of disialotransferrin and trisialotransferrin in PBC were significantly lower than those in the healthy subjects (
Identifiants
pubmed: 32911601
pii: jcm9092894
doi: 10.3390/jcm9092894
pmc: PMC7564153
pii:
doi:
Types de publication
Journal Article
Langues
eng
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