Cytochrome C Oxidase Subunit 4 (COX4): A Potential Therapeutic Target for the Treatment of Medullary Thyroid Cancer.
COX4
cancer metabolism
cytochrome-c oxidase
medullary thyroid cancer
thyroid cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
08 Sep 2020
08 Sep 2020
Historique:
received:
02
08
2020
revised:
30
08
2020
accepted:
02
09
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
12
9
2020
Statut:
epublish
Résumé
The nuclear-encoded subunit 4 of cytochrome c oxidase (COX4) plays a role in regulation of oxidative phosphorylation and contributes to cancer progression. We sought to determine the role of COX4 in differentiated (DTC) and medullary (MTC) thyroid cancers. We examined the expression of COX4 in human thyroid tumors by immunostaining and used shRNA-mediated knockdown of COX4 to evaluate its functional contributions in thyroid cancer cell lines. In human thyroid tissue, the expression of COX4 was higher in cancers than in either normal thyroid (
Identifiants
pubmed: 32911610
pii: cancers12092548
doi: 10.3390/cancers12092548
pmc: PMC7565757
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : American Thyroid Association
ID : ATAGRANT2019-0000000118
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