Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.
Asian People
/ genetics
Case-Control Studies
Genetic Association Studies
/ statistics & numerical data
Genetic Predisposition to Disease
Humans
Infertility, Male
/ epidemiology
Male
Methylenetetrahydrofolate Reductase (NADPH2)
/ genetics
Polymorphism, Single Nucleotide
Risk Factors
White People
/ genetics
MTHFR
Male infertility
Polymorphisms
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
15
06
2020
accepted:
31
08
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
22
7
2021
Statut:
epublish
Résumé
One of the possible male sterility risk factors are polymorphisms of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic investigations described inconsistent results regarding MTHFR polymorphism and the risk of male infertility. For that reason, we carried out a meta-analysis of published case-control studies to re-examine the controversy. Electronic searches of Cochrane, EMBASE, Google Scholar, and PubMed were conducted to select eligible studies for this meta-analysis (updated to May 2019). According to our exclusion and inclusion criteria, only high-quality studies that remarked the association between MTHFR polymorphisms and male infertility risk were included. The Crude odds ratio (OR) with a confidence interval of 95% (CI) was used to assess the relationship between MTHFR polymorphism and male infertility risk. Thirty-four case-control studies with 9662 cases and 9154 controls concerning 677C/T polymorphism and 22 case-control studies with 5893 cases and 6303 controls concerning 1298A/C polymorphism were recruited. Both MTHFR polymorphisms had significant associations with male infertility risk (CT + TT vs. CC: OR = 1.37, 95% CI: 1.21-1.55, P = 0.00, I Some of MTHFR polymorphisms like MTHFR 677C > T are associated with an elevated male infertility risk. To confirm our conclusion and to provide more accurate and complete gene-environment communication with male infertility risk, more analytical studies are needed.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
One of the possible male sterility risk factors are polymorphisms of Methylenetetrahydrofolate reductase (MTHFR). However, the epidemiologic investigations described inconsistent results regarding MTHFR polymorphism and the risk of male infertility. For that reason, we carried out a meta-analysis of published case-control studies to re-examine the controversy.
METHODS
METHODS
Electronic searches of Cochrane, EMBASE, Google Scholar, and PubMed were conducted to select eligible studies for this meta-analysis (updated to May 2019). According to our exclusion and inclusion criteria, only high-quality studies that remarked the association between MTHFR polymorphisms and male infertility risk were included. The Crude odds ratio (OR) with a confidence interval of 95% (CI) was used to assess the relationship between MTHFR polymorphism and male infertility risk.
RESULTS
RESULTS
Thirty-four case-control studies with 9662 cases and 9154 controls concerning 677C/T polymorphism and 22 case-control studies with 5893 cases and 6303 controls concerning 1298A/C polymorphism were recruited. Both MTHFR polymorphisms had significant associations with male infertility risk (CT + TT vs. CC: OR = 1.37, 95% CI: 1.21-1.55, P = 0.00, I
CONCLUSIONS
CONCLUSIONS
Some of MTHFR polymorphisms like MTHFR 677C > T are associated with an elevated male infertility risk. To confirm our conclusion and to provide more accurate and complete gene-environment communication with male infertility risk, more analytical studies are needed.
Identifiants
pubmed: 32912251
doi: 10.1186/s12958-020-00649-1
pii: 10.1186/s12958-020-00649-1
pmc: PMC7488080
doi:
Substances chimiques
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
93Références
Fertil Steril. 2003 Nov;80(5):1190-4
pubmed: 14607573
Genet Mol Res. 2016 Apr 26;15(2):
pubmed: 27173242
Asian Pac J Cancer Prev. 2012;13(4):1203-8
pubmed: 22799306
Mol Biol Rep. 2012 Feb;39(2):1997-2002
pubmed: 21643754
Andrology. 2020 Jan;8(1):110-116
pubmed: 31127676
Clin Appl Thromb Hemost. 2014 May;20(4):400-10
pubmed: 23188888
Andrology. 2017 Jul;5(4):704-710
pubmed: 28440964
Hum Reprod. 2010 Jun;25(6):1383-97
pubmed: 20378615
Reprod Biomed Online. 2007 Dec;15(6):643-58
pubmed: 18062861
Indian J Clin Biochem. 2017 Jul;32(3):253-260
pubmed: 28811683
PLoS One. 2015 Jul 06;10(7):e0131960
pubmed: 26147289
Fertil Steril. 2014 Jan;101(1):87-94.e3
pubmed: 24268703
Hum Reprod. 2006 Dec;21(12):3162-70
pubmed: 16861746
Int J Androl. 2012 Feb;35(1):18-24
pubmed: 21535009
PLoS One. 2009 Aug 06;4(8):e6540
pubmed: 19657388
PLoS One. 2012;7(3):e34111
pubmed: 22457816
Reprod Sci. 2011 Dec;18(12):1267-72
pubmed: 21775772
Eur J Obstet Gynecol Reprod Biol. 2017 May;212:101-109
pubmed: 28363185
Genet Mol Biol. 2015 Mar;38(1):42-7
pubmed: 25983623
Balkan J Med Genet. 2016 Aug 2;19(1):51-62
pubmed: 27785408
Mol Hum Reprod. 2007 Apr;13(4):213-22
pubmed: 17277043
Balkan J Med Genet. 2013 Jun;16(1):31-40
pubmed: 24265582
Per Med. 2019 Jan;16(1):35-49
pubmed: 30468411
Andrologia. 2012 May;44 Suppl 1:252-9
pubmed: 21729137
Int J Androl. 2005 Apr;28(2):115-9
pubmed: 15811073
Andrologia. 2017 Sep;49(7):
pubmed: 27596009
Reprod Biomed Online. 2015 Nov;31(5):668-80
pubmed: 26380869
Med Oncol. 2011 Dec;28 Suppl 1:S398-412
pubmed: 21046286
Medicine (Baltimore). 2019 Feb;98(8):e14283
pubmed: 30813130
J Androl. 2009 Nov-Dec;30(6):711-25
pubmed: 19478329
Reprod Fertil Dev. 2016 Apr;28(6):785-94
pubmed: 25412139
Asian J Androl. 2011 Nov;13(6):856-61
pubmed: 21857689
Asian J Androl. 2007 Jan;9(1):57-62
pubmed: 16888682
Eur J Med Genet. 2015 Jan;58(1):1-10
pubmed: 25449138
Aust Fam Physician. 2016 Apr;45(4):237-40
pubmed: 27052143
PLoS One. 2011;6(7):e22277
pubmed: 21799811
Hum Fertil (Camb). 2019 Apr 26;:1-7
pubmed: 31023108
Arch Iran Med. 2017 May;20(5):320-325
pubmed: 28510469
Med Arch. 2018 Jun;72(3):164-169
pubmed: 30061759
Mol Biol Rep. 2014 Feb;41(2):573-9
pubmed: 24366618
J Assist Reprod Genet. 2015 Mar;32(3):369-74
pubmed: 25578539
J Endocrinol Invest. 2003 Jul;26(7):620-2
pubmed: 14594111
Gene. 2014 Feb 15;536(1):40-4
pubmed: 24334125
Mutat Res. 2011 May-Jun;727(3):62-71
pubmed: 21540125
J Assist Reprod Genet. 2005 Oct;22(9-10):361-8
pubmed: 16247718
Biomarkers. 2006 Jan-Feb;11(1):53-60
pubmed: 16484136
Int J Clin Exp Pathol. 2017 Jul 01;10(7):7640-7649
pubmed: 31966609
Physiol Rev. 2016 Jan;96(1):55-97
pubmed: 26582516
Hum Mol Genet. 2015 Nov 15;24(22):6301-13
pubmed: 26307085
J Sports Sci. 2014;32(4):375-82
pubmed: 24015812
PLoS One. 2015 Mar 20;10(3):e0121147
pubmed: 25793386
PLoS One. 2017 Jan 12;12(1):e0169789
pubmed: 28081209