Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.
Journal
Radiation oncology (London, England)
ISSN: 1748-717X
Titre abrégé: Radiat Oncol
Pays: England
ID NLM: 101265111
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
01
07
2020
accepted:
20
08
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
6
7
2021
Statut:
epublish
Résumé
Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.
Identifiants
pubmed: 32912295
doi: 10.1186/s13014-020-01654-9
pii: 10.1186/s13014-020-01654-9
pmc: PMC7488099
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
214Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : National Institutes of Health (US)
ID : Cancer Center Support Grant P30 CA008748
Organisme : Bundesministerium für Bildung und Forschung
ID : "ZiSStrans" 02NUK047C
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2338
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