Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.
Chemotaxis
Cytokines
Microglia
Neuronal apoptosis
PI3K/Akt/mTORC1 signaling
Phagocytosis
Toll-like receptor 5
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
10 09 2020
10 09 2020
Historique:
received:
08
07
2020
accepted:
29
08
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
1
6
2021
Statut:
epublish
Résumé
Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family. Although TLR5 has previously been implicated in different CNS disorders including neurodegenerative diseases, its mode of action in the brain remained largely unexplored. We sought to determine the expression and functional consequences of TLR5 activation in the CNS. Quantitative real-time PCR and immunocytochemical analysis revealed that microglia is the major CNS cell type that constitutively expresses TLR5. Using Tlr5
Identifiants
pubmed: 32912327
doi: 10.1186/s40478-020-01031-3
pii: 10.1186/s40478-020-01031-3
pmc: PMC7488138
doi:
Substances chimiques
Tlr5 protein, mouse
0
Toll-Like Receptor 5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
159Références
Neurobiol Aging. 2009 May;30(5):759-68
pubmed: 17905482
Neuro Oncol. 2015 Feb;17(2):200-10
pubmed: 25452390
J Immunol. 2001 Aug 15;167(4):1882-5
pubmed: 11489966
Cell Mol Neurobiol. 2018 Oct;38(7):1349-1368
pubmed: 30117097
Cell Rep. 2019 Dec 10;29(11):3460-3471.e7
pubmed: 31825829
Curr Opin Neurol. 2005 Jun;18(3):315-21
pubmed: 15891419
J Immunol. 2003 May 15;170(10):5165-75
pubmed: 12734364
Clin Sci (Lond). 2011 Nov;121(9):367-87
pubmed: 21745188
Biophys J. 2015 Sep 15;109(6):1214-26
pubmed: 26276688
PLoS One. 2015 May 05;10(5):e0125910
pubmed: 25942007
Alzheimers Dement. 2009 Jul;5(4):348-60
pubmed: 19560105
J Immunol. 2009 May 1;182(9):5641-53
pubmed: 19380811
Glia. 2001 May;34(3):213-28
pubmed: 11329183
Front Cell Neurosci. 2015 Feb 02;9:28
pubmed: 25698933
Infection. 2002 Apr;30(2):104-8
pubmed: 12018467
J Neuropathol Exp Neurol. 2002 Nov;61(11):1013-21
pubmed: 12430718
J Biol Chem. 2010 Jul 9;285(28):21382-90
pubmed: 20452988
J Neuropathol Exp Neurol. 2005 Nov;64(11):991-7
pubmed: 16254493
Nat Immunol. 2006 Aug;7(8):868-74
pubmed: 16829963
Exp Neurobiol. 2017 Aug;26(4):213-226
pubmed: 28912644
Infect Immun. 2008 Oct;76(10):4385-95
pubmed: 18694963
Nature. 2007 Jan 11;445(7124):168-76
pubmed: 17151600
Cell. 2010 Mar 19;140(6):805-20
pubmed: 20303872
Infect Immun. 2000 Oct;68(10):5525-9
pubmed: 10992449
J Neuropathol Exp Neurol. 2005 Sep;64(9):754-62
pubmed: 16141784
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8514-9
pubmed: 12824464
Neurosci Lett. 2009 Mar 27;453(1):41-4
pubmed: 19429012
J Immunol. 2006 May 15;176(10):6194-201
pubmed: 16670329
J Alzheimers Dis. 2015;43(3):957-66
pubmed: 25182736
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Glia. 2010 Feb;58(3):253-63
pubmed: 19705460
Nature. 2001 Apr 26;410(6832):1099-103
pubmed: 11323673
J Neurosci. 2008 Mar 5;28(10):2320-31
pubmed: 18322079
PLoS One. 2016 Apr 01;11(4):e0152786
pubmed: 27035341
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
J Immunol. 2006 Jul 1;177(1):583-92
pubmed: 16785556
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Brain Behav Immun. 2016 Nov;58:338-347
pubmed: 27554518
Cell Rep. 2016 Oct 18;17(4):1128-1140
pubmed: 27760316
Nat Med. 2015 Nov;21(11):1326-31
pubmed: 26479925
Nat Rev Immunol. 2009 Jun;9(6):429-39
pubmed: 19461673
FASEB J. 2004 Feb;18(2):412-4
pubmed: 14688201
J Biol Chem. 2006 Jul 7;281(27):18560-8
pubmed: 16644730
J Neuropathol Exp Neurol. 2016 May;75(5):429-40
pubmed: 27030742
J Immunol. 2004 Sep 15;173(6):3916-24
pubmed: 15356140
J Neurochem. 1999 May;72(5):2215-8
pubmed: 10217305
Science. 2012 Feb 17;335(6070):859-64
pubmed: 22344444
Brain Struct Funct. 2016 Mar;221(2):1157-72
pubmed: 25523105
J Neurosci. 2007 Nov 21;27(47):13033-41
pubmed: 18032677
Infect Immun. 2005 Apr;73(4):2344-50
pubmed: 15784580
Elife. 2020 Jan 28;9:
pubmed: 31989925
J Neurosci. 2002 Apr 1;22(7):2478-86
pubmed: 11923412
Transl Psychiatry. 2017 May 9;7(5):e1120
pubmed: 28485733
Glia. 2013 Apr;61(4):539-49
pubmed: 23355222
J Biol Chem. 2019 Aug 30;294(35):12921-12932
pubmed: 31296663
J Immunol. 2001 Jan 15;166(2):1248-60
pubmed: 11145708
Nat Neurosci. 2016 Jan;19(1):20-7
pubmed: 26713745
J Immunol. 2007 May 15;178(10):6476-81
pubmed: 17475877
Surg Neurol. 2000 Jan;53(1):86-90
pubmed: 10697239
J Neuroinflammation. 2011 Aug 04;8:90
pubmed: 21816039
J Exp Med. 2018 Sep 3;215(9):2247-2264
pubmed: 30158114
Nat Neurosci. 2012 Jun;15(6):827-35
pubmed: 22610069
Nat Rev Microbiol. 2017 Mar;15(3):149-159
pubmed: 28090076
Mol Neurobiol. 2019 Sep;56(9):6539-6550
pubmed: 30852796
Curr Top Microbiol Immunol. 2009;336:105-20
pubmed: 19688330
Biotechniques. 2010 Feb;48(2):121-4
pubmed: 20359295
Acta Neuropathol Commun. 2019 Feb 14;7(1):20
pubmed: 30764877