Incident pulmonary arterial hypertension associated with Bosutinib.
Macitentan
chronic myeloid leukemia
drug-induced pulmonary hypertension
tyrosine kinase inhibitors
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Historique:
received:
03
03
2020
accepted:
29
05
2020
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
12
9
2020
Statut:
epublish
Résumé
Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug-induced pulmonary arterial hypertension. There have been case reports linking Bosutinib with deterioration of pre-existing pulmonary arterial hypertension. Here, we present a case of a 37-year-old woman with chronic myeloid leukemia treated with Bosutinib who was diagnosed with pulmonary arterial hypertension. Prior to Bosutinib, she had received Dasatinib without documented cardiopulmonary toxicity. Withdrawal of Bosutinib led to partial reversal of pulmonary arterial hypertension, and with the addition of pulmonary arterial hypertension-targeted treatment, there was near normalization of hemodynamics.
Identifiants
pubmed: 32913629
doi: 10.1177/2045894020936913
pii: 10.1177_2045894020936913
pmc: PMC7443988
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2045894020936913Informations de copyright
© The Author(s) 2020.
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