Clinical and genetic characteristics of patients with Doose syndrome.

Doose syndrome HNRNPU SLC6A1 STS comorbidity

Journal

Epilepsia open
ISSN: 2470-9239
Titre abrégé: Epilepsia Open
Pays: United States
ID NLM: 101692036

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 23 01 2020
revised: 19 06 2020
accepted: 28 06 2020
entrez: 11 9 2020
pubmed: 12 9 2020
medline: 12 9 2020
Statut: epublish

Résumé

To elucidate the genetic background and genotype-phenotype correlations for epilepsy with myoclonic-atonic seizures, also known as myoclonic-astatic epilepsy (MAE) or Doose syndrome. We collected clinical information and blood samples from 29 patients with MAE. We performed whole-exome sequencing for all except one MAE case in whom custom capture sequencing identified a variant. We newly identified four variants: MAE patients had genetic heterogeneity, and

Identifiants

pubmed: 32913952
doi: 10.1002/epi4.12417
pii: EPI412417
pmc: PMC7469791
doi:

Types de publication

Journal Article

Langues

eng

Pagination

442-450

Informations de copyright

© 2020 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

Déclaration de conflit d'intérêts

None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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Auteurs

Nodoka Hinokuma (N)

Department of Pediatrics Showa University School of Medicine Tokyo Japan.

Mitsuko Nakashima (M)

Department of Biochemistry Hamamatsu University School of Medicine Hamamatsu Japan.
Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Hideyuki Asai (H)

Department of Pediatrics Showa University School of Medicine Tokyo Japan.

Kazuyuki Nakamura (K)

Department of Pediatrics Yamagata University Faculty of Medicine Yamagata Japan.

Shinjiro Akaboshi (S)

Department of Pediatrics Tottori Medical Center Tottori Japan.

Masataka Fukuoka (M)

Shizuoka Institute of Epilepsy and Neurological Disorders Shizuoka Japan.

Masami Togawa (M)

Department of Pediatrics Tottori Prefectural Central Hospital Tottori Japan.

Shingo Oana (S)

Department of Pediatrics Tokyo Medical University Tokyo Japan.

Koyo Ohno (K)

Division of Child Neurology Institute of Neurological Sciences Faculty of Medicine Tottori University Yonago Japan.

Mariko Kasai (M)

Department of Developmental Medical Sciences Graduate School of Medicine The University of Tokyo Tokyo Japan.

Chikako Ogawa (C)

Department of Pediatrics Nagoya University Graduate School of Medicine Aichi Japan.

Kazuna Yamamoto (K)

Department of Pediatrics Teikyo University School of Medicine Tokyo Japan.

Kiyohito Okumiya (K)

Department of Pediatrics and Child Health Kurume University School of Medicine Fukuoka Japan.

Pin Fee Chong (PF)

Department of Pediatric Neurology Fukuoka Children's Hospital Fukuoka Japan.

Ryutaro Kira (R)

Department of Pediatric Neurology Fukuoka Children's Hospital Fukuoka Japan.

Shumpei Uchino (S)

Department of Neuropediatrics Tokyo Metropolitan Neurological Hospital Tokyo Japan.
Department of Pediatrics The University of Tokyo Tokyo Japan.

Tetsuhiro Fukuyama (T)

Department of Pediatrics Shinshu University School of Medicine Matsumoto Japan.

Tomoe Shinagawa (T)

Department of Pediatrics Aomori City Hospital Aomori Japan.

Yohane Miyata (Y)

Department of Pediatrics Kyorin University Faculty of Medicine Tokyo Japan.

Yuichi Abe (Y)

Department of Pediatrics Saitama Medical University Moroyama Japan.
Division of Neurology National Center for Child Health and Development Tokyo Japan.

Akira Hojo (A)

Department of Pediatrics Showa University School of Medicine Tokyo Japan.

Kozue Kobayashi (K)

Department of Pediatrics Showa University School of Medicine Tokyo Japan.

Yoshihiro Maegaki (Y)

Division of Child Neurology Institute of Neurological Sciences Faculty of Medicine Tottori University Yonago Japan.

Nobutsune Ishikawa (N)

Department of Pediatrics Hiroshima University Hospital Hiroshima Japan.

Hiroko Ikeda (H)

Shizuoka Institute of Epilepsy and Neurological Disorders Shizuoka Japan.

Masano Amamoto (M)

Kitakyushu City Yahata Hospital Pediatric Emergency/Children's Medical Center Fukuoka Japan.

Takeshi Mizuguchi (T)

Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Kazuhiro Iwama (K)

Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Toshiyuki Itai (T)

Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Satoko Miyatake (S)

Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Hirotomo Saitsu (H)

Department of Biochemistry Hamamatsu University School of Medicine Hamamatsu Japan.
Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Naomichi Matsumoto (N)

Department of Human Genetics Yokohama City University Graduate School of Medicine Yokohama Japan.

Mitsuhiro Kato (M)

Department of Pediatrics Showa University School of Medicine Tokyo Japan.
Department of Pediatrics Yamagata University Faculty of Medicine Yamagata Japan.

Classifications MeSH