BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer.
Clinicopathological parameters
Gastric cancer
Long non-coding RNA BC032913
qRT-PCR
Journal
Journal of gastrointestinal cancer
ISSN: 1941-6636
Titre abrégé: J Gastrointest Cancer
Pays: United States
ID NLM: 101479627
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
pubmed:
12
9
2020
medline:
19
1
2022
entrez:
11
9
2020
Statut:
ppublish
Résumé
Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression. The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC. QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated. BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters. LncRNA BC032913 may be considered as an impressive therapeutic target for GC.
Sections du résumé
BACKGROUND
BACKGROUND
Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.
OBJECTIVE
OBJECTIVE
The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.
METHODS
METHODS
QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.
RESULTS
RESULTS
BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.
CONCLUSION
CONCLUSIONS
LncRNA BC032913 may be considered as an impressive therapeutic target for GC.
Identifiants
pubmed: 32914372
doi: 10.1007/s12029-020-00517-6
pii: 10.1007/s12029-020-00517-6
doi:
Substances chimiques
RNA, Long Noncoding
0
BCO1 protein, human
EC 1.14.99.36
beta-Carotene 15,15'-Monooxygenase
EC 1.14.99.36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
928-931Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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