Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low-Metabolic Ectotherms.

axolotl comparative physiology ectotherm endotherm heart regeneration metabolism zebrafish

Journal

BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851

Informations de publication

Date de publication:
11 2020
Historique:
received: 11 03 2020
revised: 12 08 2020
pubmed: 12 9 2020
medline: 19 8 2021
entrez: 11 9 2020
Statut: ppublish

Résumé

The heart has a high-metabolic rate, and its "around-the-clock" vital role to sustain life sets it apart in a regenerative setting from other organs and appendages. The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms-for example, fish, salamanders, and embryonic/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is exclusively limited to the low-metabolic hearts of ectotherms. The biomedical field of regenerative medicine seeks to devise biologically inspired regenerative therapies to diseased human hearts. Falsification of the ectothermy dependency for heart regeneration hypothesis may be a crucial prerequisite to meaningfully seek inspiration in established ectothermic regenerative animal models. Otherwise, engineering approaches to construct artificial heart components may constitute a more viable path toward regenerative therapies. A more strict definition of regenerative phenomena is generated and several testable sub-hypotheses and experimental avenues are put forward to elucidate the link between heart regeneration and metabolism. Also see the video abstract here https://youtu.be/fZcanaOT5z8.

Identifiants

pubmed: 32914411
doi: 10.1002/bies.202000054
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000054

Subventions

Organisme : Lundbeckfonden
ID : R324-2019-1470
Pays : International
Organisme : Fonden til Laegevidenskabens Fremme
ID : 17-L-0200
Pays : International

Informations de copyright

© 2020 The Authors. BioEssays published by Wiley Periodicals LLC.

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Auteurs

Anita Dittrich (A)

Department of Clinical Medicine (Comparative Medicine Lab), Aarhus University, Aarhus N, 8200, Denmark.

Kasper Hansen (K)

Department of Clinical Medicine (Comparative Medicine Lab), Aarhus University, Aarhus N, 8200, Denmark.
Department of Forensic Medicine, Aarhus University, Aarhus N, 8200, Denmark.
Department of Biology (Zoophysiology), Aarhus University, Aarhus C, 8000, Denmark.
Leicester Royal Infirmary (East Midlands Forensic Pathology Unit), University of Leicester, Leicester, LE2 7LX, UK.

Mette Irene Theilgaard Simonsen (MIT)

Department of Clinical Medicine (Nuclear Medicine and PET), Aarhus University, Aarhus N, 8200, Denmark.

Morten Busk (M)

Department of Oncology (Experimental Clinical Oncology), Aarhus University Hospital, Aarhus N, 8200, Denmark.
Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus N, 8200, Denmark.

Aage Kristian Olsen Alstrup (AKO)

Department of Clinical Medicine (Nuclear Medicine and PET), Aarhus University, Aarhus N, 8200, Denmark.

Henrik Lauridsen (H)

Department of Clinical Medicine (Comparative Medicine Lab), Aarhus University, Aarhus N, 8200, Denmark.

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