Vitamin D Receptor Gene Polymorphism and the Risk of Multiple Sclerosis in the Azeri Population of Iran.
Adult
Case-Control Studies
Diet
/ adverse effects
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Iran
/ epidemiology
Male
Multiple Sclerosis
/ diagnosis
Polymorphism, Single Nucleotide
Receptors, Calcitriol
/ genetics
Red Meat
/ adverse effects
Risk Assessment
Risk Factors
Sunlight
Young Adult
Iran.
VDR
multiple sclerosis
polymorphism
sun exposure
vitamin D
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
04
2020
revised:
02
06
2020
accepted:
10
08
2020
pubmed:
12
9
2020
medline:
27
1
2022
entrez:
11
9
2020
Statut:
ppublish
Résumé
Multiple sclerosis (MS), a disease of the central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is a way to exert its function. Possible correlation between the vitamin D receptor (VDR) gene and MS was evaluated in the Azeri population of Iran. Different genotypes of the Bsml site were determined by using the PCR-RFLP method in 148 MS patients and 220 non-relative healthy controls. In MS patients, genotype bb was significantly higher than the healthy controls (p<0.05). Additionally, most subjects of the MS group had been insufficiently exposed to sunlight before the age of 15 (p<0.001). Our findings indicated that the red meat intake in MS patients was significantly higher than the healthy controls (p<0.001). In addition, the healthy controls had appropriate dieting behaviors in comparison to MS patients (excessive intake of some foods) (p=0.0001). In conclusion, genotype BB and sufficient exposure to sunlight before the age of 15 were the protective factors against MS. Although, excessive consumption of red meat and inappropriate dieting behaviors were predisposing factors to MS disease.
Sections du résumé
BACKGROUND
BACKGROUND
Multiple sclerosis (MS), a disease of the central nervous system (CNS), is associated with damage to the myelin sheath of neurons. It is demonstrated that vitamin D deficiency plays an important role in the development of the disease. Binding of vitamin D to its specific nuclear receptors is a way to exert its function.
OBJECTIVE
OBJECTIVE
Possible correlation between the vitamin D receptor (VDR) gene and MS was evaluated in the Azeri population of Iran.
METHODS
METHODS
Different genotypes of the Bsml site were determined by using the PCR-RFLP method in 148 MS patients and 220 non-relative healthy controls.
RESULTS
RESULTS
In MS patients, genotype bb was significantly higher than the healthy controls (p<0.05). Additionally, most subjects of the MS group had been insufficiently exposed to sunlight before the age of 15 (p<0.001). Our findings indicated that the red meat intake in MS patients was significantly higher than the healthy controls (p<0.001). In addition, the healthy controls had appropriate dieting behaviors in comparison to MS patients (excessive intake of some foods) (p=0.0001).
CONCLUSION
CONCLUSIONS
In conclusion, genotype BB and sufficient exposure to sunlight before the age of 15 were the protective factors against MS. Although, excessive consumption of red meat and inappropriate dieting behaviors were predisposing factors to MS disease.
Identifiants
pubmed: 32914731
pii: EMIDDT-EPUB-109859
doi: 10.2174/1871530320666200910113954
doi:
Substances chimiques
Receptors, Calcitriol
0
VDR protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1306-1311Subventions
Organisme : Tabriz University of Medical Sciences
ID : 816
Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.