Growth rate alterations of human colorectal cancer cells by 157 gut bacteria.
Colorectal cancer
MTT assay
cell proliferation
human microbiome
secretomes
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
entrez:
11
9
2020
pubmed:
12
9
2020
medline:
28
9
2021
Statut:
ppublish
Résumé
Several bacteria in the human gut microbiome have been associated with colorectal cancer (CRC) by high-throughput screens. In some cases, molecular mechanisms have been elucidated that drive tumorigenesis, including bacterial membrane proteins or secreted molecules that interact with the human cancer cells. For most gut bacteria, however, it remains unknown if they enhance or inhibit cancer cell growth. Here, we screened bacteria-free supernatants (secretomes) and inactivated cells of over 150 cultured bacterial strains for their effects on cell growth. We observed family-level and strain-level effects that often differed between bacterial cells and secretomes, suggesting that different molecular mechanisms are at play. Secretomes of
Identifiants
pubmed: 32915102
doi: 10.1080/19490976.2020.1799733
pmc: PMC7524400
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-20Références
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