Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the Sleep-Wake Cycle.
alertness
circadian
napping
optogenetics
siesta
sleep
vasoactive intestinal polypeptide
wake maintenance
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
received:
30
06
2019
revised:
07
10
2019
accepted:
31
07
2020
pubmed:
12
9
2020
medline:
29
12
2020
entrez:
11
9
2020
Statut:
ppublish
Résumé
Although the mammalian rest-activity cycle is controlled by a "master clock" in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual SCN neurons gates individual features of daily activity. Here, we demonstrate that a specific transcriptomically identified population of mouse VIP+ SCN neurons is active at the "wrong" time of day-nighttime-when most SCN neurons are silent. Using chemogenetic and optogenetic strategies, we show that these neurons and their cellular clocks are necessary and sufficient to gate and time nighttime sleep but have no effect upon daytime sleep. We propose that mouse nighttime sleep, analogous to the human siesta, is a "hard-wired" property gated by specific neurons of the master clock to favor subsequent alertness prior to dawn (a circadian "wake maintenance zone"). Thus, the SCN is not simply a 24-h metronome: specific populations sculpt critical features of the sleep-wake cycle.
Identifiants
pubmed: 32916091
pii: S0896-6273(20)30608-5
doi: 10.1016/j.neuron.2020.08.001
pmc: PMC7803671
pii:
doi:
Substances chimiques
Vasoactive Intestinal Peptide
37221-79-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
486-499.e5Subventions
Organisme : Medical Research Council
ID : MC_U105170643
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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