Warmth Prevents Bone Loss Through the Gut Microbiota.

Animals Cells, Cultured Gastrointestinal Microbiome Humans Male Mice Mice, Inbred C57BL Osteoporosis / metabolism Ovariectomy
bone metabolomics metadata metagenomics microbiota osteoporosis ovariectomy polyamines post-menopause warm

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
06 10 2020
Historique:
received: 19 02 2020
revised: 25 06 2020
accepted: 18 08 2020
pubmed: 12 9 2020
medline: 9 11 2021
entrez: 11 9 2020
Statut: ppublish

Résumé

Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.

Identifiants

DOI: 10.1016/j.cmet.2020.08.012 PMID: 32916104 PMC: PMC7116155
pubmed: 32916104
pii: S1550-4131(20)30425-3
doi: 10.1016/j.cmet.2020.08.012
pmc: PMC7116155
mid: EMS94822
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

575-590.e7

Subventions

Organisme : European Research Council
ID : 815962
Pays : International

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests M.T. and C.C. disclose that they are inventors of a submitted patent application for treatment of bone diseases. All other authors declare no competing interests.

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Auteurs

Claire Chevalier (C)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Silas Kieser (S)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Melis Çolakoğlu (M)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Noushin Hadadi (N)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Julia Brun (J)

Division of Bone Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.

Dorothée Rigo (D)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Nicolas Suárez-Zamorano (N)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Martina Spiljar (M)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Salvatore Fabbiano (S)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Björn Busse (B)

Institute for Osteology and Biomechanics, University Clinics Hamburg, 22529 Hamburg, Germany.

Julijana Ivanišević (J)

Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland.

Andrew Macpherson (A)

Department for Biomedical Research, University of Bern, University Clinics for Visceral Surgery and Medicine, Inselspital, Bern University Hospitals, 3008 Bern, Switzerland.

Nicolas Bonnet (N)

Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Division of Bone Diseases, Geneva University Hospitals, 1211 Geneva, Switzerland.

Mirko Trajkovski (M)

Department of Cell Physiology and Metabolism, Centre Médical Universitaire (CMU), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland. Electronic address: mirko.trajkovski@unige.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Cellules › Cellules cultivées › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Warmth Prevents Bone Loss Through the Gut Microbiota.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Ovariectomie › Warmth Prevents Bone Loss Through the Gut Microbiota.