Protein crowding in the inner mitochondrial membrane.

Animals Humans Mitochondria / metabolism Mitochondrial Membranes / metabolism Mitochondrial Proteins / metabolism
Cardiolipin Lipids Membrane Mitochondria Protein

Journal

Biochimica et biophysica acta. Bioenergetics
ISSN: 1879-2650
Titre abrégé: Biochim Biophys Acta Bioenerg
Pays: Netherlands
ID NLM: 101731706

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 27 07 2020
revised: 24 08 2020
accepted: 03 09 2020
pubmed: 12 9 2020
medline: 14 4 2021
entrez: 11 9 2020
Statut: ppublish

Résumé

The inner membrane of mitochondria is known for its low lipid-to-protein ratio. Calculations based on the size and the concentration of the principal membrane components, suggest about half of the hydrophobic volume of the membrane is occupied by proteins. Such high degree of crowding is expected to strain the hydrophobic coupling between proteins and lipids unless stabilizing mechanisms are in place. Both protein supercomplexes and cardiolipin are likely to be critical for the integrity of the inner mitochondrial membrane because they reduce the energy penalty of crowding.

Identifiants

DOI: 10.1016/j.bbabio.2020.148305 PMID: 32916174
pubmed: 32916174
pii: S0005-2728(20)30155-9
doi: 10.1016/j.bbabio.2020.148305
pii:
doi:

Substances chimiques

Mitochondrial Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

148305

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM115593
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Michael Schlame (M)

Departments of Anesthesiology and Cell Biology, New York University School of Medicine, NY 10016, USA. Electronic address: michael.schlame@med.nyu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Protein crowding in the inner mitochondrial membrane.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Protein crowding in the inner mitochondrial membrane.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Protein crowding in the inner mitochondrial membrane.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Membranes intracellulaires › Membranes mitochondriales › Protein crowding in the inner mitochondrial membrane.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protein crowding in the inner mitochondrial membrane.