Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T.
Directional DBS
Functional magnetic resonance imaging
High frequency stimulation
Motor cortex
Orientation selective DBS
Somatosensory cortex
Thalamus
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
14
09
2019
revised:
27
08
2020
accepted:
04
09
2020
pubmed:
12
9
2020
medline:
30
3
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
Functional MRI (fMRI) has become an important tool for probing network-level effects of deep brain stimulation (DBS). Previous DBS-fMRI studies have shown that electrical stimulation of the ventrolateral (VL) thalamus can modulate sensorimotor cortices in a frequency and amplitude dependent manner. Here, we investigated, using a swine animal model, how the direction and orientation of the electric field, induced by VL-thalamus DBS, affects activity in the sensorimotor cortex. Adult swine underwent implantation of a novel 16-electrode (4 rows x 4 columns) directional DBS lead in the VL thalamus. A within-subject design was used to compare fMRI responses for (1) directional stimulation consisting of monopolar stimulation in four radial directions around the DBS lead, and (2) orientation-selective stimulation where an electric field dipole was rotated 0°-360° around a quadrangle of electrodes. Functional responses were quantified in the premotor, primary motor, and somatosensory cortices. High frequency electrical stimulation through leads implanted in the VL thalamus induced directional tuning in cortical response patterns to varying degrees depending on DBS lead position. Orientation-selective stimulation showed maximal functional response when the electric field was oriented approximately parallel to the DBS lead, which is consistent with known axonal orientations of the cortico-thalamocortical pathway. These results demonstrate that directional and orientation-selective stimulation paradigms in the VL thalamus can tune network-level modulation patterns in the sensorimotor cortex, which may have translational utility in improving functional outcomes of DBS therapy.
Identifiants
pubmed: 32916285
pii: S1053-8119(20)30843-0
doi: 10.1016/j.neuroimage.2020.117357
pmc: PMC7783780
mid: NIHMS1658694
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
117357Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094206
Pays : United States
Organisme : NINDS NIH HHS
ID : P50 NS098573
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS103569
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS118756
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081118
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Neurology. 1996 Apr;46(4):1150-3
pubmed: 8780109
Brain Stimul. 2008 Jan;1(1):7-15
pubmed: 19142235
Exp Brain Res. 1996 May;109(2):219-39
pubmed: 8738372
Neuroimage. 2015 Jan 15;105:181-8
pubmed: 25451479
Radiology. 1991 Jun;179(3):777-81
pubmed: 2027991
J Comp Neurol. 1987 Aug 15;262(3):331-64
pubmed: 2821085
Hum Brain Mapp. 2009 Jul;30(7):2021-31
pubmed: 18726909
Cell Tissue Bank. 2011 Aug;12(3):219-31
pubmed: 20589432
Parkinsonism Relat Disord. 2014 Apr;20(4):471-3
pubmed: 24041939
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:677-80
pubmed: 22254400
Magn Reson Imaging. 2013 Jun;31(5):783-8
pubmed: 23228310
Lancet. 1991 Feb 16;337(8738):403-6
pubmed: 1671433
Acta Neurochir (Wien). 2012 Mar;154(3):495-9
pubmed: 22109693
J Neural Eng. 2019 Feb;16(1):016026
pubmed: 30275348
Neuroimage Clin. 2018;20:1246-1254
pubmed: 30420259
Mov Disord. 2016 Aug;31(8):1240-3
pubmed: 27241197
J Neural Eng. 2018 Dec;15(6):066020
pubmed: 30211697
Front Comput Neurosci. 2016 Jun 10;10:58
pubmed: 27375470
Magn Reson Imaging. 2012 Nov;30(9):1323-41
pubmed: 22770690
Brain Behav Evol. 1985;27(1):28-40
pubmed: 3836731
IEEE Trans Biomed Eng. 2012 Jun;59(6):1583-92
pubmed: 22410323
Arch Med Res. 2000 May-Jun;31(3):266-9
pubmed: 11036177
Brain Stimul. 2018 May - Jun;11(3):600-606
pubmed: 29373260
J Neural Eng. 2017 Feb;14(1):016014
pubmed: 28068291
Neurosurgery. 2004 May;54(5):1120-29; discussion 1129-30
pubmed: 15113466
J Anat. 1995 Dec;187 ( Pt 3):583-92
pubmed: 8586557
Mov Disord. 2006 Nov;21(11):1920-8
pubmed: 16972236
J Comp Neurol. 2001 Aug 20;437(2):170-85
pubmed: 11494250
Mov Disord. 2017 Oct;32(10):1380-1388
pubmed: 28843009
J Neurosurg. 2011 Aug;115(2):310-5
pubmed: 21548744
Neuroimage. 2007 Aug 15;37(2):508-17
pubmed: 17590355
Brain Res. 1983 May;286(3):237-65
pubmed: 6189561
J Neurophysiol. 1980 Sep;44(3):532-54
pubmed: 7441314
Neuroscience. 2006 Dec 28;143(4):987-1020
pubmed: 17055664
J Comp Neurol. 2003 Mar 3;457(2):133-58
pubmed: 12541315
Neurology. 2001 May 22;56(10):1347-54
pubmed: 11376186
Neuroimage. 2016 Mar;128:138-148
pubmed: 26780572
Parkinsonism Relat Disord. 2016 Oct;31:156-158
pubmed: 27591075
J Neurosci Methods. 2010 Sep 30;192(1):102-9
pubmed: 20692291
J Cereb Blood Flow Metab. 1987 Oct;7(5):649-58
pubmed: 3498733
Neuroimage. 2012 Nov 15;63(3):1408-20
pubmed: 22967832
Stereotact Funct Neurosurg. 2013;91(1):24-9
pubmed: 23154815
J Neural Eng. 2018 Oct;15(5):056029
pubmed: 30095084
Stereotact Funct Neurosurg. 2009;87(5):297-303
pubmed: 19641340
Neuroimage. 2003 Feb;18(2):517-24
pubmed: 12595204
Brain. 2016 Aug;139(Pt 8):2198-210
pubmed: 27329768
Front Neurosci. 2019 Sep 18;13:985
pubmed: 31619955
J Neural Eng. 2018 Dec;15(6):066003
pubmed: 30124202
Neurology. 2014 Sep 23;83(13):1163-9
pubmed: 25150285
Clin Neurophysiol. 2004 Mar;115(3):589-95
pubmed: 15036055
Biol Psychiatry. 2013 Dec 15;74(12):917-926
pubmed: 23993641
Brain Res Bull. 1999 May;49(1-2):1-137
pubmed: 10466025
J Neural Eng. 2012 Aug;9(4):046005
pubmed: 22732947
Clin Neurophysiol. 2011 Mar;122(3):558-566
pubmed: 20729143
J Neural Eng. 2013 Oct;10(5):056023
pubmed: 24060691
J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):273-6
pubmed: 9489548
Acta Neurochir (Wien). 2007 Aug;149(8):749-58; discussion 758
pubmed: 17660940
J Neural Eng. 2017 Feb;14(1):016016
pubmed: 28068296
IEEE Trans Biomed Eng. 2016 Jan;63(1):148-57
pubmed: 26529747
Brain. 2014 Jul;137(Pt 7):2015-26
pubmed: 24844728
Mov Disord. 2002;17 Suppl 3:S9-14
pubmed: 11948750
Clin Neurophysiol. 2005 Sep;116(9):2240-50
pubmed: 16055377