Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome.
Aged
Butyrates
/ pharmacology
Cerebral Cortex
/ metabolism
Dopamine Plasma Membrane Transport Proteins
/ metabolism
Double-Blind Method
Fecal Microbiota Transplantation
/ methods
Feces
/ microbiology
Female
Gastrointestinal Microbiome
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Male
Metabolic Syndrome
/ metabolism
Microbiota
Middle Aged
Obesity
/ metabolism
Serotonin Plasma Membrane Transport Proteins
/ metabolism
Gut-brain axis
Gutmicrobiota
Metabolites
Obesity
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
07
2020
revised:
31
08
2020
accepted:
04
09
2020
pubmed:
12
9
2020
medline:
8
9
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on ( We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. 4488.
Identifiants
pubmed: 32916306
pii: S2212-8778(20)30150-2
doi: 10.1016/j.molmet.2020.101076
pmc: PMC7536740
pii:
doi:
Substances chimiques
Butyrates
0
Dopamine Plasma Membrane Transport Proteins
0
Insulin
0
Serotonin Plasma Membrane Transport Proteins
0
Banques de données
NTR
['NTR4713']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101076Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier GmbH.. All rights reserved.
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