Lung carcinoids with high proliferative activity: Further support for the identification of a new tumor category in the classification of lung neuroendocrine neoplasms.
Carcinoids
Ki67
Lung
Neuroendocrine neoplasms
Journal
Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
01
2020
revised:
16
07
2020
accepted:
03
08
2020
pubmed:
12
9
2020
medline:
22
6
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
Highly proliferative lung carcinoids (HPLC) have been recently reported but information about this subset remains scarce. Clinical and pathological data of 630 patients with lung carcinoids (LC) referred to Gustave Roussy Institute (GR) and European Institute of Oncology (IEO) were retrospectively reviewed to select HPLC and analyze their frequency, behavior and compare their outcome to conventional LC with Ki-67 ≤ 20 % and mitotic count (MC)≤10/2 mm Selection criteria were: diagnosis of LC confirmed by local pathologist, and available clinical and follow-up data. Patients with Ki-67 > 20 % and/or MC > 10/ 2 mm2 in primary or metastatic specimens were identified as HPLC. 30/514 patients (6%) met the selection criteria of HPLC. Based on primary tumor evaluation, 22/25 (88 %) were classified as atypical carcinoids (AC). Median MC was 4.5/2 mm This study confirms the existence and rarity of HPLC. Their characteristics and clinical behavior are more similar to LC rather than neuroendocrine carcinomas (NECs), suggesting that this entity could be managed accordingly.
Identifiants
pubmed: 32916569
pii: S0169-5002(20)30562-6
doi: 10.1016/j.lungcan.2020.08.001
pii:
doi:
Substances chimiques
Ki-67 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-158Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.