Proteome-wide Changes in the

Disease Pathophysiology Proteomics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
25 Sep 2020
Historique:
received: 11 03 2020
revised: 30 06 2020
accepted: 21 08 2020
medline: 12 9 2020
pubmed: 12 9 2020
entrez: 11 9 2020
Statut: epublish

Résumé

Duchenne muscular dystrophy is primarily characterized by progressive muscle wasting due to deficiency in the membrane cytoskeletal protein dystrophin but is also associated with body-wide cellular disturbances in a variety of non-muscle tissues. In this study, we have focused on the comparative proteomic analysis of the spleen and established considerable changes in this crucial secondary lymphoid organ from the genetic

Identifiants

pubmed: 32916630
pii: S2589-0042(20)30692-1
doi: 10.1016/j.isci.2020.101500
pmc: PMC7490529
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101500

Informations de copyright

© 2020 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Paul Dowling (P)

Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co. Kildare W23F2H6, Ireland.
Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare W23F2H6, Ireland.

Stephen Gargan (S)

Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co. Kildare W23F2H6, Ireland.
Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare W23F2H6, Ireland.

Margit Zweyer (M)

Department of Neonatology and Paediatric Intensive Care, Children's Hospital, University of Bonn, 53113 Bonn, Germany.

Michael Henry (M)

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

Paula Meleady (P)

National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland.

Dieter Swandulla (D)

Institute of Physiology II, University of Bonn, 53115 Bonn, Germany.

Kay Ohlendieck (K)

Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co. Kildare W23F2H6, Ireland.
Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare W23F2H6, Ireland.

Classifications MeSH