Pilea umbrosa ameliorate CCl
Animals
Carbon Tetrachloride
/ adverse effects
Chemical and Drug Induced Liver Injury
/ drug therapy
Endoplasmic Reticulum Stress
/ drug effects
Fibrosis
/ drug therapy
Inflammation
/ drug therapy
Liver
/ drug effects
Male
Protective Agents
/ pharmacology
Rats
Rats, Sprague-Dawley
Urticaceae
/ chemistry
Antioxidant
Cytokines
ER stress
Liver
RT-PCR
Journal
Environmental health and preventive medicine
ISSN: 1347-4715
Titre abrégé: Environ Health Prev Med
Pays: Japan
ID NLM: 9609642
Informations de publication
Date de publication:
11 Sep 2020
11 Sep 2020
Historique:
received:
23
10
2019
accepted:
01
09
2020
entrez:
12
9
2020
pubmed:
13
9
2020
medline:
30
9
2020
Statut:
epublish
Résumé
Pilea umbrosa (Urticaceae) is used by local communities (district Abbotabad) for liver disorders, as anticancer, in rheumatism and in skin disorders. Methanol extract of P. umbrosa (PUM) was investigated for the presence of polyphenolic constituents by HPLC-DAD analysis. PUM (150 mg/kg and 300 mg/kg) was administered on alternate days for eight weeks in rats exposed with carbon tetrachloride (CCl Level of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and glutathione (GSH) decreased (p < 0.05) whereas level of thiobarbituric acid reactive substance (TBARS), H Collectively these results suggest that PUM constituted of strong antioxidant chemicals and could be a potential therapeutic agent for stress related liver disorders.
Sections du résumé
BACKGROUND
BACKGROUND
Pilea umbrosa (Urticaceae) is used by local communities (district Abbotabad) for liver disorders, as anticancer, in rheumatism and in skin disorders.
METHODS
METHODS
Methanol extract of P. umbrosa (PUM) was investigated for the presence of polyphenolic constituents by HPLC-DAD analysis. PUM (150 mg/kg and 300 mg/kg) was administered on alternate days for eight weeks in rats exposed with carbon tetrachloride (CCl
RESULTS
RESULTS
Level of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and glutathione (GSH) decreased (p < 0.05) whereas level of thiobarbituric acid reactive substance (TBARS), H
CONCLUSION
CONCLUSIONS
Collectively these results suggest that PUM constituted of strong antioxidant chemicals and could be a potential therapeutic agent for stress related liver disorders.
Identifiants
pubmed: 32917140
doi: 10.1186/s12199-020-00893-2
pii: 10.1186/s12199-020-00893-2
pmc: PMC7488709
doi:
Substances chimiques
Protective Agents
0
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
53Références
Mol Pharmacol. 2009 Oct;76(4):884-95
pubmed: 19620254
PLoS One. 2014 Jun 11;9(2):e97125
pubmed: 24918756
Food Chem Toxicol. 2013 Nov;61:60-8
pubmed: 23380202
Food Chem. 2014 Jan 1;142:121-8
pubmed: 24001821
Expert Rev Gastroenterol Hepatol. 2016;10(2):243-53
pubmed: 26634783
Transfus Med Rev. 2004 Jul;18(3):153-67
pubmed: 15248165
Mol Cell Biol. 2003 Oct;23(20):7198-209
pubmed: 14517290
Biomed Pharmacother. 2018 Sep;105:1117-1132
pubmed: 30021348
J Ethnopharmacol. 2011 Nov 18;138(2):523-9
pubmed: 22001857
Nat Med. 2012 Jul 06;18(7):1028-40
pubmed: 22772564
Fish Shellfish Immunol. 2015 Jun;44(2):533-41
pubmed: 25827627
J Hepatol. 2014 Aug;61(2):193-5
pubmed: 24650692
Methods Enzymol. 1996;268:237-46
pubmed: 8782590
J Ethnopharmacol. 2004 Mar;91(1):43-50
pubmed: 15036466
Toxicol Ind Health. 2011 Nov;27(10):923-33
pubmed: 21511893
Int J Cancer. 2000 Oct 1;88(1):7-11
pubmed: 10962433
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):804-818
pubmed: 29217140
Gut. 2018 Sep;67(9):1568-1594
pubmed: 29593060
Biochim Biophys Acta. 2016 Aug;1863(8):2115-23
pubmed: 27155082
Stem Cell Res Ther. 2014 Nov 06;5(6):122
pubmed: 25376879
BMC Complement Altern Med. 2013 Mar 18;13:64
pubmed: 23506615
Eur J Nutr. 2014 Feb;53(1):187-99
pubmed: 23515587
Ann Trop Med Parasitol. 2006 Jan;100(1):69-74
pubmed: 16417716
Cell Immunol. 1981 Apr;59(2):301-18
pubmed: 6269759
Biomed Pharmacother. 2018 Nov;107:1601-1610
pubmed: 30257378
Nutr Metab (Lond). 2012 Mar 30;9(1):27
pubmed: 22458550
Exp Oncol. 2012 Oct;34(3):286-97
pubmed: 23070014
Toxicol Res (Camb). 2019 Nov 14;8(6):815-832
pubmed: 34055308
Biochem Biophys Res Commun. 1998 Jun 18;247(2):397-400
pubmed: 9642139
Food Nutr Res. 2015 Sep 07;59:28438
pubmed: 26350293
Clin Interv Aging. 2007;2(3):377-87
pubmed: 18044188
Toxicol Lett. 2013 Jun 20;220(1):82-7
pubmed: 23615074
Toxicol Appl Pharmacol. 2015 Jul 15;286(2):102-11
pubmed: 25827057
J Sep Sci. 2015 Nov;38(22):3870-3875
pubmed: 26376932
BMC Med. 2014 Sep 18;12:145
pubmed: 25242656
J Clin Biochem Nutr. 2010 Sep;47(2):148-54
pubmed: 20838570
World J Biol Chem. 2011 Oct 26;2(10):226-31
pubmed: 22031845
J Med Food. 2020 Nov;23(11):1192-1200
pubmed: 32125927
Methods Enzymol. 1984;105:121-6
pubmed: 6727660
Sci Rep. 2017 Mar 31;7:45846
pubmed: 28361988
Anal Chem. 2009 Oct 1;81(19):8085-93
pubmed: 19715299
J Ethnopharmacol. 2014 Dec 2;158 Pt A:230-8
pubmed: 25456431
Indian J Biochem Biophys. 1984 Apr;21(2):130-2
pubmed: 6490072
Nat Protoc. 2006;1(2):581-5
pubmed: 17406285
J Biol Chem. 1951 Nov;193(1):265-75
pubmed: 14907713