Dose-dependent effects of transcranial alternating current stimulation on spike timing in awake nonhuman primates.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
29
08
2019
accepted:
16
07
2020
entrez:
12
9
2020
pubmed:
13
9
2020
medline:
13
4
2022
Statut:
epublish
Résumé
Weak extracellular electric fields can influence spike timing in neural networks. Approaches to noninvasively impose these fields on the brain have high therapeutic potential in neurology and psychiatry. Transcranial alternating current stimulation (TACS) is hypothesized to affect spike timing and cause neural entrainment. However, the conditions under which these effects occur in vivo are unknown. Here, we recorded single-unit activity in the neocortex in awake nonhuman primates during TACS and found dose-dependent neural entrainment to the stimulation waveform. Cluster analysis of changes in interspike intervals identified two main types of neural responses to TACS-increased burstiness and phase entrainment. Our results uncover key mechanisms of TACS and show that the stimulation affects spike timing in the awake primate brain at intensities feasible in humans. Thus, novel TACS protocols tailored to ongoing brain activity may be a tool to normalize spike timing in maladaptive brain networks and neurological disease.
Identifiants
pubmed: 32917605
pii: 6/36/eaaz2747
doi: 10.1126/sciadv.aaz2747
pmc: PMC7467690
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : P50 NS098573
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS108625
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS037019
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS077657
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094206
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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