The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR test for diagnosing COVID-19 using convalescent antibody as a comparator.
Antibodies, Viral
/ blood
Asymptomatic Infections
Betacoronavirus
/ genetics
COVID-19
COVID-19 Testing
Clinical Laboratory Techniques
/ standards
Coronavirus Infections
/ blood
False Negative Reactions
Humans
Pandemics
Pneumonia, Viral
/ blood
Reverse Transcriptase Polymerase Chain Reaction
/ standards
SARS-CoV-2
Sensitivity and Specificity
Thorax
/ virology
COVID-19
COVID-19 antibody
SARS-CoV-2 RT-PCR
clinical sensitivity
Journal
Clinical medicine (London, England)
ISSN: 1473-4893
Titre abrégé: Clin Med (Lond)
Pays: England
ID NLM: 101092853
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
pubmed:
13
9
2020
medline:
1
12
2020
entrez:
12
9
2020
Statut:
ppublish
Résumé
The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing, use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis.
Identifiants
pubmed: 32917746
pii: clinmed.2020-0555
doi: 10.7861/clinmed.2020-0555
pmc: PMC7687334
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e209-e211Informations de copyright
© 2020 Royal College of Physicians 2020. All rights reserved.
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