Loss of smell in patients with COVID-19: MRI data reveal a transient edema of the olfactory clefts.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
08 12 2020
08 12 2020
Historique:
received:
05
08
2020
accepted:
21
08
2020
pubmed:
13
9
2020
medline:
16
12
2020
entrez:
12
9
2020
Statut:
ppublish
Résumé
To assess the physiopathology of olfactory function loss (OFL) in patients with coronavirus disease 2019 (COVID-19), we evaluated the olfactory clefts (OC) on MRI during the early stage of the disease and 1 month later. This was a prospective, monocentric, case-controlled study. Twenty severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected patients with OFL were included and compared to 20 age-matched healthy controls. All infected patients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at the 1-month follow-up. At the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 ± 2.7 (range 0-8), and MRI displayed a complete obstruction of the OC in 19 of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At the 1 month follow-up, the olfactory score had improved to 8.3 ± 1.9 (range 4-10) in patients, and only 7 of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC ( OFL in SARS-CoV2-infected patients is associated with a reversible obstruction of the OC.
Identifiants
pubmed: 32917809
pii: WNL.0000000000010806
doi: 10.1212/WNL.0000000000010806
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3145-e3152Informations de copyright
© 2020 American Academy of Neurology.