Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease.
Adult
Aged
Aged, 80 and over
Alzheimer Disease
/ genetics
Brain
/ metabolism
Case-Control Studies
Creutzfeldt-Jakob Syndrome
/ genetics
DNA Methylation
/ physiology
Female
Genetic Predisposition to Disease
/ genetics
Humans
Male
Middle Aged
Prion Diseases
/ metabolism
Shaker Superfamily of Potassium Channels
/ genetics
Blood
DNA methylation
Disease duration
Neurodegeneration
Prion disease
sCJD
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
10
07
2020
accepted:
31
08
2020
revised:
13
08
2020
pubmed:
13
9
2020
medline:
22
9
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative disorders, no study has yet explored their role in human prion diseases. Here we profiled genome-wide blood DNA methylation in the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD). Our case-control study (n = 219), when accounting for differences in cell type composition between individuals, identified 38 probes at genome-wide significance (p < 1.24 × 10
Identifiants
pubmed: 32918118
doi: 10.1007/s00401-020-02224-9
pii: 10.1007/s00401-020-02224-9
pmc: PMC7666287
doi:
Substances chimiques
Shaker Superfamily of Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
863-879Subventions
Organisme : Medical Research Council
ID : MC_U123160657
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U123160651
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00024/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00024/9
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400713
Pays : United Kingdom
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