Sex-specific peripheral and central responses to stress-induced depression and treatment in a mouse model.
chronic social defeat stress
differential gene expression
major depressive disorder
peripheral inflammation
prefrontal cortex
sex dimorphism
stress disorder
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
12
2019
revised:
17
06
2020
accepted:
15
08
2020
pubmed:
13
9
2020
medline:
18
9
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
Major depressive disorder affects ~20% of the world population and is characterized by strong sexual dimorphism with females being two to three times more likely to develop this disorder. Previously, we demonstrated that a combination therapy with dihydrocaffeic acid and malvidin-glucoside to synergistically target peripheral inflammation and stress-induced synaptic maladaptation in the brain was effective in alleviating chronic social defeat stress (CSDS)-induced depression-like phenotype in male mice. Here, we test the combination therapy in a female CSDS model for depression and compared sex-specific responses to stress in the periphery and the central nervous system. Similar to male mice, the combination treatment is also effective in promoting resilience against the CSDS-induced depression-like behavior in female mice. However, there are sex-specific differences in peripheral immune responses and differential gene regulation in the prefrontal cortex to chronic stress and to the treatment. These data indicate that while therapeutic approaches to combat stress-related disorders may be effective in both sexes, the mechanisms underlying these effects differ, emphasizing the need for inclusion of both sexes in preclinical studies using animal models.
Identifiants
pubmed: 32918293
doi: 10.1002/jnr.24724
pmc: PMC8561614
mid: NIHMS1740330
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2541-2553Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104559
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH087004
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH127820
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH090264
Pays : United States
Organisme : NCCIH NIH HHS
ID : P50 AT008661
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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