Review: Helicobacter pylori infection in children.


Journal

Helicobacter
ISSN: 1523-5378
Titre abrégé: Helicobacter
Pays: England
ID NLM: 9605411

Informations de publication

Date de publication:
Sep 2020
Historique:
entrez: 12 9 2020
pubmed: 13 9 2020
medline: 2 7 2021
Statut: ppublish

Résumé

Helicobacter pylori infection in children and adolescents differs in comparison to adults with respect to epidemiology, host responses, and disease manifestations. Furthermore, treatment options are limited in this population and antibiotic resistance rates continue to increase. Therefore, ongoing research is vital to understand disease pathogenesis and provide optimal management of children with infection. This review summarizes relevant publications from April 2019 to March 2020. Similar to adults, recent studies show a decreasing prevalence of infection in the pediatric population. Studies of pathogenesis investigated serum immune responses and the potential inverse association of infection and allergy. Several studies investigated the effect of H pylori and related inflammation on the gut microbiome. The recommendation of endoscopy-based testing to identify the cause of symptoms and not just H pylori, reserving noninvasive UBT or stool antigen tests for post-eradication follow-up, was supported by the current literature.

Identifiants

pubmed: 32918353
doi: 10.1111/hel.12742
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e12742

Informations de copyright

© 2020 John Wiley & Sons Ltd.

Références

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Auteurs

Ji-Hyun Seo (JH)

Department of Pediatrics, Gyeongsang National Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Korea.

Kristen Bortolin (K)

Department of Paediatrics, Division of Gastroenterology Hepatology and Nutrition, University of Toronto, SickKids, Toronto, Canada.

Nicola L Jones (NL)

Departments of Paediatrics and Physiology, Division of Gastroenterology Hepatology and Nutrition, Cell Biology Program, SickKids Research Institute, University of Toronto, SickKids, Toronto, Canada.

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