Functional topography of the thalamo-cortical system during development and its relation to cognition.
Adolescent
Adolescent Development
/ physiology
Adult
Brain Mapping
Cerebral Cortex
/ growth & development
Child
Child Development
/ physiology
Child, Preschool
Cognition
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Neural Pathways
/ physiology
Neuropsychological Tests
Thalamus
/ growth & development
Young Adult
Functional connectivity
MRI
Rs-fMRI
Sub-nuclei
Subcortical
Thalamo-cortical
Thalamus
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
05
2020
revised:
04
09
2020
accepted:
07
09
2020
pubmed:
13
9
2020
medline:
9
3
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
The thalamus has complex connections with the cortex and is involved in various cognitive processes. However, little is known about the age-related changes of thalamo-cortical connections and their relation to cognitive abilities. The present study analyzed resting-state functional connectivity between the thalamus and nine cortical functional networks (default mode network (DMN), posterior DMN, left/right executive, dorsal attention, salience, motor, visual and auditory network) in a healthy human sample (N = 95, aged 5-25 years). Cognitive abilities, including processing speed, selective attention, and cognitive flexibility were assessed using neuropsychological tests. All nine cortical resting-state networks showed functional connections to the thalamus at rest, with no effect for sex (p > 0.05). For the motor, visual, auditory, DMN, posterior DMN, salience and dorsal attention network, we found mainly bilateral thalamic projections in the mediodorsal nucleus, pulvinar and in nuclei of the lateral group. For the right and left lateralized executive network, corresponding lateralized thalamic projections were found. Thalamo-cortical connectivity strength showed significant age-related changes from distinct sub-nuclei of the thalamus to different cortical networks including the visual, DMN, salience and dorsal attention network. Further, connectivity strength of thalamo-cortical networks was associated with cognitive abilities, including processing speed, selective attention and cognitive flexibility. Better cognitive abilities were associated with increased thalamo-cortical connectivity in the pulvinar, mediodorsal nucleus, intralaminar nucleus, and nuclei from the lateral group. Alterations in the integrity of the thalamo-cortical system seem to be crucial for the development of cognitive abilities during brain maturation.
Identifiants
pubmed: 32919055
pii: S1053-8119(20)30847-8
doi: 10.1016/j.neuroimage.2020.117361
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117361Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declarations of Competing Interest None.