Enantiomeric 8-O-4'-type neolignans from Crataegus pinnatifida exhibit cytotoxic effect via apoptosis and autophagy in Hep3B cells.
Antineoplastic Agents
/ chemistry
Apoptosis
/ drug effects
Autophagy
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Crataegus
/ chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Lignans
/ chemistry
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
Tumor Cells, Cultured
8-O-4′-type neolignans
Apoptosis
Autophagy
Crataegus pinnatifida
Enantiomers
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
31
07
2020
revised:
29
08
2020
accepted:
31
08
2020
pubmed:
14
9
2020
medline:
30
3
2021
entrez:
13
9
2020
Statut:
ppublish
Résumé
Crataegus pinnatifida has been famous for its nutritional purpose. However, systematic investigation on the bioactive constituents is still lacking, although this fruit has been reported for its cytotoxic effect before. In this study, two pairs of new lignan enantiomers (1a/1b, 2a/2b), which isolated using chiral chromatographic column from the fruits of C. pinnatifida were studied. The absolute configurations of enantiomers were determined by comparison between the experimental electronic circular dichroism (ECD) and calculated ECD spectra. Among them, 1a/1b exhibited a better cytotoxic effect in hepatocellular carcinoma Hep3B cells with an IC
Identifiants
pubmed: 32920350
pii: S0045-2068(20)31565-0
doi: 10.1016/j.bioorg.2020.104267
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Lignans
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104267Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.