Correlation study on methoxylation pattern of flavonoids and their heme-targeted antiplasmodial activity.
Antimalarials
/ chemical synthesis
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Flavonoids
/ chemical synthesis
Heme
/ antagonists & inhibitors
Human Umbilical Vein Endothelial Cells
/ drug effects
Humans
Molecular Structure
Plasmodium falciparum
/ drug effects
Structure-Activity Relationship
Heme-binding
Hemozoin
Plasmodium falciparum
Polymethoxyflavone
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
04
04
2020
revised:
22
08
2020
accepted:
25
08
2020
pubmed:
14
9
2020
medline:
30
3
2021
entrez:
13
9
2020
Statut:
ppublish
Résumé
A library of 33 polymethoxylated flavones (PMF) was evaluated for heme-binding affinity by biomimetic MS assay and in vitro antiplasmodial activity on two strains of P. falciparum. Stability of heme adducts was discussed using the dissociation voltage at 50% (DV
Identifiants
pubmed: 32920360
pii: S0045-2068(20)31541-8
doi: 10.1016/j.bioorg.2020.104243
pii:
doi:
Substances chimiques
Antimalarials
0
Flavonoids
0
Heme
42VZT0U6YR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104243Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.