Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements.
Cell Biology
Omics
Toxicology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
13
11
2019
revised:
17
07
2020
accepted:
26
08
2020
medline:
14
9
2020
pubmed:
14
9
2020
entrez:
13
9
2020
Statut:
epublish
Résumé
Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3' end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA, causing transformation of human cells
Identifiants
pubmed: 32920490
pii: S2589-0042(20)30710-0
doi: 10.1016/j.isci.2020.101518
pmc: PMC7492993
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101518Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES030583
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES026138
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022935
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES000260
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133712
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA204439
Pays : United States
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.