Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine.
Anticoagulants
/ therapeutic use
COVID-19
/ diagnosis
Cardiology
Cardiovascular Diseases
/ diagnosis
Europe
Heparin, Low-Molecular-Weight
/ therapeutic use
Humans
Inflammation
Practice Guidelines as Topic
Risk Factors
Rivaroxaban
/ therapeutic use
SARS-CoV-2
/ physiology
Societies, Medical
Thrombophilia
Thrombosis
COVID-19 Drug Treatment
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
14
9
2020
medline:
29
1
2021
entrez:
13
9
2020
Statut:
ppublish
Résumé
COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.
Identifiants
pubmed: 32920811
doi: 10.1055/s-0040-1715798
pmc: PMC7869052
doi:
Substances chimiques
Anticoagulants
0
Heparin, Low-Molecular-Weight
0
Rivaroxaban
9NDF7JZ4M3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1597-1628Investigateurs
Behnood Bikdeli
(B)
Yutao Guo
(Y)
Job Harenberg
(J)
Yu Hu
(Y)
Gregory Y H Lip
(GYH)
Vanessa Roldan
(V)
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.
Références
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Blood Adv. 2018 Nov 27;2(22):3198-3225
pubmed: 30482763
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Am J Hypertens. 2020 Oct 21;33(10):944-948
pubmed: 32511678
Shock. 1998 Apr;9(4):274-81
pubmed: 9565256
N Engl J Med. 2013 Feb 7;368(6):513-23
pubmed: 23388003
J Am Soc Nephrol. 2020 Sep;31(9):1948-1958
pubmed: 32660970
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Thromb Haemost. 2020 Jul;120(7):1004-1024
pubmed: 32473596
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):e244-e245
pubmed: 32294273
Pharmacol Res. 2020 Aug;158:104950
pubmed: 32450344
Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):259-67
pubmed: 18158647
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Respir Care. 2020 Jul;65(7):1039-1045
pubmed: 32047121
Clin Appl Thromb Hemost. 2018 Dec;24(9_suppl):8S-28S
pubmed: 30296833
J Am Coll Cardiol. 2017 Jul 4;70(1):1-25
pubmed: 28527533
Br J Haematol. 2020 Jun;189(6):1044-1049
pubmed: 32330308
Crit Care. 2020 Jun 16;24(1):353
pubmed: 32546188
Int Angiol. 2013 Apr;32(2):111-260
pubmed: 24402349
J Thromb Haemost. 2020 Aug;18(8):2066-2067
pubmed: 32344457
Biochem Biophys Res Commun. 2007 Jul 20;359(1):174-9
pubmed: 17533109
J Thromb Haemost. 2018 Jul;16(7):1278-1287
pubmed: 29753308
Thromb Haemost. 2020 Dec;120(12):1680-1690
pubmed: 32961572
J Eur Acad Dermatol Venereol. 2020 May;34(5):e212-e213
pubmed: 32215952
Clin Appl Thromb Hemost. 2008 Oct;14(4):385-92
pubmed: 18815137
J Am Coll Cardiol. 2020 Jul 7;76(1):122-124
pubmed: 32387623
Postgrad Med J. 2020 Jul;96(1137):403-407
pubmed: 32522846
Pharmacol Res. 2017 Sep;123:146-156
pubmed: 28161237
Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e006273
pubmed: 29954742
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
J Thromb Haemost. 2007 May;5(5):955-62
pubmed: 17461929
J Infect. 2020 Aug;81(2):e16-e25
pubmed: 32335169
Thromb Res. 2020 Aug;192:113-115
pubmed: 32425261
J Clin Invest. 2002 Jul;110(1):127-36
pubmed: 12093896
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Hamostaseologie. 2020 Aug;40(3):264-269
pubmed: 32498097
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):529-530
pubmed: 32203680
Cell Metab. 2020 Jun 2;31(6):1068-1077.e3
pubmed: 32369736
Chest. 2012 Feb;141(2 Suppl):e195S-e226S
pubmed: 22315261
Crit Care Med. 2020 Sep;48(9):1358-1364
pubmed: 32467443
Molecules. 2020 May 29;25(11):
pubmed: 32485894
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
Am J Ther. 2022 Jul 01;29(4):e385-e393
pubmed: 31833874
Thromb Haemost. 2016 Apr;115(4):712-28
pubmed: 26676884
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
TH Open. 2020 Mar 13;4(1):e59-e65
pubmed: 32190813
J Thromb Haemost. 2020 Jul;18(7):1743-1746
pubmed: 32320517
JAAD Case Rep. 2020 Apr 18;6(6):489-492
pubmed: 32363225
Clin Res Cardiol. 2020 May;109(5):531-538
pubmed: 32161990
Int J Legal Med. 2020 Jul;134(4):1275-1284
pubmed: 32500199
J Am Heart Assoc. 2014 Nov 17;3(6):e001152
pubmed: 25404191
Thromb Haemost. 2003 Mar;89(3):561-72
pubmed: 12624642
J Thromb Thrombolysis. 2020 Jul;50(1):211-216
pubmed: 32451823
J Thromb Haemost. 2020 Jul;18(7):1747-1751
pubmed: 32302448
Eur Heart J. 2020 May 14;41(19):1858
pubmed: 32227120
Circulation. 2020 Jun 9;141(23):1930-1936
pubmed: 32243205
J Thromb Haemost. 2020 Sep;18(9):2391-2399
pubmed: 32558198
Br J Haematol. 2020 Jun;189(5):846-847
pubmed: 32304577
Int Angiol. 2018 Aug;37(4):327-334
pubmed: 29936722
J Thromb Haemost. 2020 Jun;18(6):1324-1329
pubmed: 32306492
Thromb Res. 2020 Jul;191:148-150
pubmed: 32381264
Arch Med Sci. 2020 Apr 25;16(3):490-496
pubmed: 32399094
Vasa. 2020 Mar;49(2):133-140
pubmed: 31808732
J Thromb Haemost. 2020 Apr;18(4):844-847
pubmed: 32073213
Histopathology. 2020 Aug;77(2):198-209
pubmed: 32364264
Clin Exp Dermatol. 2020 Aug;45(6):746-748
pubmed: 32302422
Nephron. 2017;137(2):113-123
pubmed: 28662505
Pulm Ther. 2020 Dec;6(2):169-176
pubmed: 32405877
Am J Hematol. 2020 Jul;95(7):834-847
pubmed: 32282949
Br J Haematol. 2020 Jun;189(6):1060-1061
pubmed: 32400024
Thromb Res. 2020 Sep;193:86-89
pubmed: 32531548
BMJ. 2006 Feb 11;332(7537):325-9
pubmed: 16439370
Clin Pharmacokinet. 2018 Oct;57(10):1347-1354
pubmed: 29453687
Thromb Res. 2019 Feb;174:48-50
pubmed: 30554045
J Thromb Haemost. 2013 Feb 4;:
pubmed: 23379279
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):e251-e252
pubmed: 32294270
Thromb Haemost. 2014 Nov;112(5):941-6
pubmed: 25030937
J Med Internet Res. 2020 Jun 12;22(6):e19938
pubmed: 32490843
Thromb Haemost. 2001 Nov;86(5):1327-30
pubmed: 11816725
Thromb Res. 2018 Apr;164 Suppl 1:S62-S69
pubmed: 29703486
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
J Am Heart Assoc. 2021 Jul 6;10(13):e018086
pubmed: 33624516
Res Pract Thromb Haemost. 2018 Jul 17;2(4):696-707
pubmed: 30349889
N Engl J Med. 1999 Sep 9;341(11):793-800
pubmed: 10477777
Lancet Infect Dis. 2020 Oct;20(10):1135-1140
pubmed: 32526193
Blood. 2020 Jun 4;135(23):2033-2040
pubmed: 32339221
Radiology. 2020 Sep;296(3):E186-E188
pubmed: 32324103
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):e246-e247
pubmed: 32294259
Clin Chem Lab Med. 2020 Jun 25;58(7):1029-1036
pubmed: 32406381
Res Pract Thromb Haemost. 2018 Nov 15;3(1):18-25
pubmed: 30656272
J Thromb Haemost. 2020 May;18(5):1023-1026
pubmed: 32338827
J Thromb Haemost. 2020 Jun;18(6):1320-1323
pubmed: 32329231
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Thromb Haemost. 2020 Jun;120(6):949-956
pubmed: 32349133
J Thromb Thrombolysis. 2021 Feb;51(2):446-453
pubmed: 33151461
J Am Coll Cardiol. 2020 May 12;75(18):2352-2371
pubmed: 32201335
Virchows Arch. 2020 Sep;477(3):359-372
pubmed: 32642842
Int J Infect Dis. 2020 Jul;96:615-617
pubmed: 32502659
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
J Am Acad Dermatol. 2020 Aug;83(2):700
pubmed: 32283229
Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619876030
pubmed: 31530176
Curr Atheroscler Rep. 2018 Feb 14;20(3):12
pubmed: 29445885
Atherosclerosis. 2020 Jan;293:92-93
pubmed: 31822359
J Vasc Surg. 2020 Dec;72(6):1864-1872
pubmed: 32360679
Intensive Care Med. 2020 Jun;46(6):1089-1098
pubmed: 32367170
JAMA. 2001 Oct 17;286(15):1869-78
pubmed: 11597289
Am J Emerg Med. 2020 Jul;38(7):1504-1507
pubmed: 32317203
Res Pract Thromb Haemost. 2020 Jun 09;4(4):518-523
pubmed: 32542212
Biochem Biophys Rep. 2016 Sep;7:180-187
pubmed: 28758151
Thromb Res. 2020 Jul;191:9-14
pubmed: 32353746
Radiology. 2020 Sep;296(3):E189-E191
pubmed: 32324102
Zhonghua Bing Li Xue Za Zhi. 2020 Jun 8;49(6):568-575
pubmed: 32486534
Curr Atheroscler Rep. 2004 Sep;6(5):381-7
pubmed: 15296705
Influenza Other Respir Viruses. 2017 Jan;11(1):85-92
pubmed: 27542891
J Thromb Haemost. 2020 Jul;18(7):1752-1755
pubmed: 32267998
Lancet Respir Med. 2020 Jul;8(7):681-686
pubmed: 32473124
Am J Physiol Endocrinol Metab. 2020 Jul 1;319(1):E197-E202
pubmed: 32501731
Lancet Infect Dis. 2020 Dec;20(12):1365-1366
pubmed: 32359410
Circulation. 2004 Aug 17;110(7):874-9
pubmed: 15289368
Pharmacol Rev. 2016 Jan;68(1):76-141
pubmed: 26672027
J Thromb Haemost. 2020 Aug;18(8):1995-2002
pubmed: 32369666
J Thromb Haemost. 2020 Aug;18(8):2058-2060
pubmed: 32324960
Blood. 1997 Nov 15;90(10):3819-43
pubmed: 9354649
Mem Inst Oswaldo Cruz. 2020;115:e200179
pubmed: 32490889
Nat Rev Microbiol. 2019 Mar;17(3):181-192
pubmed: 30531947
J Thromb Thrombolysis. 2020 Oct;50(3):543-547
pubmed: 32519165
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Chest. 2020 Sep;158(3):1143-1163
pubmed: 32502594
J Eur Acad Dermatol Venereol. 2020 Jun;34(6):e250-e251
pubmed: 32294264
Ann Hematol. 2020 Jul;99(7):1421-1428
pubmed: 32495027
Hosp Pract (1995). 2020 Oct;48(4):169-179
pubmed: 32429774
J Am Acad Dermatol. 2020 Jul;83(1):e57-e60
pubmed: 32339706
PLoS Biol. 2005 Oct;3(10):e324
pubmed: 16128623
J Thromb Thrombolysis. 2020 Jul;50(1):72-81
pubmed: 32440883
Ann Intern Med. 2010 Jul 6;153(1):8-18
pubmed: 20621900
Neth Heart J. 2020 Jul;28(7-8):396-405
pubmed: 32514935
Semin Thromb Hemost. 2000;26 Suppl 1:5-21
pubmed: 11011802
Crit Care Med. 2020 Sep;48(9):e799-e804
pubmed: 32452888
J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973
pubmed: 32311448
J Thromb Haemost. 2020 Aug;18(8):1859-1865
pubmed: 32459046
Sci China Life Sci. 2020 Mar;63(3):364-374
pubmed: 32048163
Thromb Haemost. 2010 Mar;103(3):572-85
pubmed: 20135071
J Clin Invest. 2020 Aug 3;130(8):3950-3953
pubmed: 32459663
Lancet Haematol. 2020 Jun;7(6):e438-e440
pubmed: 32407672
Front Immunol. 2019 Jul 26;10:1731
pubmed: 31402914
Chest. 2011 Sep;140(3):706-714
pubmed: 21436241
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32329756
J Trauma Acute Care Surg. 2020 Sep;89(3):448-452
pubmed: 32427774
JAMA Intern Med. 2020 Jul 1;180(7):934-943
pubmed: 32167524
J Clin Virol. 2020 Jun;127:104354
pubmed: 32305882
Lancet. 2020 May 16;395(10236):1546
pubmed: 32423583
J Thromb Thrombolysis. 2020 Aug;50(2):287-291
pubmed: 32445064
J Trauma Acute Care Surg. 2020 Sep;89(3):453-457
pubmed: 32427773
Br J Dermatol. 2020 Oct;183(4):729-737
pubmed: 32562567
Inflamm Res. 2001 Dec;50(12):581-4
pubmed: 11822782
J Thromb Haemost. 2020 Jul;18(7):1738-1742
pubmed: 32302438
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
N Engl J Med. 2020 Apr 23;382(17):e38
pubmed: 32268022
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Chin Med J (Engl). 2020 Jun 5;133(11):1261-1267
pubmed: 32209890
Blood. 2018 Apr 26;131(17):1903-1909
pubmed: 29483100
J Pathol. 2001 Jan;193(1):134-40
pubmed: 11169526
Histopathology. 2020 Aug;77(2):186-197
pubmed: 32443177
J Thromb Thrombolysis. 2020 Aug;50(2):298-301
pubmed: 32476080
Eur J Clin Pharmacol. 2015 Aug;71(8):921-9
pubmed: 26071276
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Circ Res. 2016 Feb 19;118(4):620-36
pubmed: 26892962
J Thromb Haemost. 2020 Aug;18(8):2067-2068
pubmed: 32407600
Clin Pharmacol Ther. 2019 Jan;105(1):219-228
pubmed: 29696643
Thromb Res. 2020 Aug;192:152-160
pubmed: 32485418
N Engl J Med. 2020 Apr 30;382(18):e43
pubmed: 32294340
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1372-1379
pubmed: 32242738
Int J Cardiol. 2007 Mar 20;116(2):174-9
pubmed: 16901564
Int J Lab Hematol. 2020 Jun;42 Suppl 1:19-20
pubmed: 32311843
Crit Care. 2018 Mar 8;22(1):60
pubmed: 29519254
N Engl J Med. 2018 Sep 20;379(12):1118-1127
pubmed: 30145946
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508
Blood. 2020 Jul 23;136(4):489-500
pubmed: 32492712
N Engl J Med. 2016 Aug 11;375(6):534-44
pubmed: 27232649
J Med Econ. 2019 Oct;22(10):1063-1072
pubmed: 31314619
Thromb Haemost. 2020 Jun;120(6):937-948
pubmed: 32316065