Changes in Function and Dynamics in Hepatic and Splenic Macrophages in Non-Alcoholic Fatty Liver Disease.
EGFP mouse
M1-type macrophage
NAFLD
NASH
STAM mouse
bone marrow transplantation
tissue macrophage
Journal
Clinical and experimental gastroenterology
ISSN: 1178-7023
Titre abrégé: Clin Exp Gastroenterol
Pays: New Zealand
ID NLM: 101532800
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
02
2020
accepted:
27
07
2020
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
15
9
2020
Statut:
epublish
Résumé
The aim of this study was to investigate the populations and functions of hepatic and splenic macrophages (Mfs) in non-alcoholic fatty liver disease (NAFLD). Experiment 1: Wild-type and STAM Experiment 1: The number of CD68-positive cells and the percentage of F4/80-positive/CD68-positive cells increased with the progression of NAFLD. Production of TNF-α and IL-6 by hepatic Mfs was greater than that by splenic Mfs in mice with NASH. The number of CD14 The populations and functions of hepatic and splenic Mfs are altered during the progression of NAFLD. In addition, increased hepatic Mfs during the progression of NAFLD may migrate from bone marrow to the liver via the spleen.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to investigate the populations and functions of hepatic and splenic macrophages (Mfs) in non-alcoholic fatty liver disease (NAFLD).
MATERIALS AND METHODS
METHODS
Experiment 1: Wild-type and STAM
RESULTS
RESULTS
Experiment 1: The number of CD68-positive cells and the percentage of F4/80-positive/CD68-positive cells increased with the progression of NAFLD. Production of TNF-α and IL-6 by hepatic Mfs was greater than that by splenic Mfs in mice with NASH. The number of CD14
CONCLUSION
CONCLUSIONS
The populations and functions of hepatic and splenic Mfs are altered during the progression of NAFLD. In addition, increased hepatic Mfs during the progression of NAFLD may migrate from bone marrow to the liver via the spleen.
Identifiants
pubmed: 32922061
doi: 10.2147/CEG.S248635
pii: 248635
pmc: PMC7457821
doi:
Types de publication
Journal Article
Langues
eng
Pagination
305-314Informations de copyright
© 2020 Fukushima et al.
Déclaration de conflit d'intérêts
All authors have no financial and personal relationships with other people or organizations that could potentially and inappropriately influence (bias) their work and conclusions. The authors report no conflicts of interest in this work.
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