The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis.

buffering dosing histidine containing dipeptides meta-analysis metabolism nutrition physiology supplement

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2020
Historique:
received: 21 05 2020
accepted: 08 07 2020
entrez: 14 9 2020
pubmed: 15 9 2020
medline: 15 9 2020
Statut: epublish

Résumé

Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions on the nature of the MCarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and application of this supplementation strategy. To address these questions, we conducted a systematic review with Bayesian-based meta-analysis of all published aggregate data using a dose response (Emax) model. Meta-regression was used to consider the influence of potential moderators (including dose, sex, age, baseline MCarn, and analysis method used) on the primary outcome. The protocol was designed according to PRISMA guidelines and a three-step screening strategy was undertaken to identify studies that measured the MCarn response to BA supplementation. Additionally, we conducted an original analysis of all available individual data on the MCarn response to BA supplementation from studies conducted within our lab (

Identifiants

DOI: 10.3389/fphys.2020.00913 PMID: 32922303 PMC: PMC7456894
pubmed: 32922303
doi: 10.3389/fphys.2020.00913
pmc: PMC7456894
doi:

Types de publication

Systematic Review

Langues

eng

Pagination

913

Informations de copyright

Copyright © 2020 Rezende, Swinton, de Oliveira, da Silva, da Eira Silva, Nemezio, Yamaguchi, Artioli, Gualano, Saunders and Dolan.

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Auteurs

Nathália Saffioti Rezende (NS)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Paul Swinton (P)

School of Health Sciences, Robert Gordon University, Aberdeen, United Kingdom.

Luana Farias de Oliveira (LF)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Rafael Pires da Silva (RP)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Vinicius da Eira Silva (V)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Kleiner Nemezio (K)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Guilherme Yamaguchi (G)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Guilherme Giannini Artioli (GG)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Bruno Gualano (B)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
Food Research Center, University of São Paulo, São Paulo, Brazil.

Bryan Saunders (B)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Eimear Dolan (E)

Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Rheumatology Division, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Classifications MeSH