Dexamethasone premedication suppresses vaccine-induced immune responses against cancer.
Glucocorticosteroids
RNA vaccine
T-cell priming
T-cell vaccine
cancer immunotherapy
dexamethasone
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
13 05 2020
13 05 2020
Historique:
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
15
9
2020
Statut:
epublish
Résumé
Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated
Identifiants
pubmed: 32923115
doi: 10.1080/2162402X.2020.1758004
pii: 1758004
pmc: PMC7458619
doi:
Substances chimiques
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Langues
eng
Pagination
1758004Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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