Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells.
CD36
Cancer stem cells
lung cancer
metastasis
monocytes/macrophages
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
15
9
2020
Statut:
epublish
Résumé
The 'cancer cell fusion' theory is controversial due to the lack of methods available to identify hybrid cells and to follow the phenomenon in patients. However, it seems to be one of the best explanations for both the origin and metastasis of primary tumors. Herein, we co-cultured lung cancer stem cells with human monocytes and analyzed the dynamics and properties of tumor-hybrid cells (THC), as well as the molecular mechanisms beneath this fusion process by several techniques: electron-microscopy, karyotyping, CRISPR-Cas9, RNA-seq, immunostaining, signaling blockage, among others. Moreover, mice models were assessed for
Identifiants
pubmed: 32923132
doi: 10.1080/2162402X.2020.1773204
pii: 1773204
pmc: PMC7458638
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1773204Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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