BOTOX injection to treat strabismus after infant botulism type B infection.
Botulinum immunoglobulin
Botulinum toxin
Botulism
Strabismus
Journal
American journal of ophthalmology case reports
ISSN: 2451-9936
Titre abrégé: Am J Ophthalmol Case Rep
Pays: United States
ID NLM: 101679941
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
07
01
2020
revised:
22
04
2020
accepted:
16
08
2020
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
15
9
2020
Statut:
epublish
Résumé
The significance of botulinum toxin to ophthalmologists is twofold. Botulism, a medical emergency, frequently presents with ocular findings including blurred vision, diplopia, ptosis, and photophobia as a result of the neurotoxin produced by Clostridium botulinum. However, botulinum toxins also have therapeutic uses for medical conditions including strabismus. The safety and efficacy of Botulinum toxin A in patients with a history of botulism has not been reported. We report a 9-week-old infant, diagnosed with type B toxin positive infant botulism treated with human botulism immune globulin, who developed a large angle exotropia. The infant was treated with intramuscular injections of botulinum toxin A to the extraocular muscles resulting in a favorable initial response but ultimately required strabismus surgery. Clinical manifestations and management of botulism are reviewed and botulinum toxin in the treatment of pediatric strabismus is discussed. This case demonstrates safe administration of onabotulinumtoxinA to an infant with a history of antitoxin-treated botulism, resulting in a transient improvement in control of infantile exotropia.
Identifiants
pubmed: 32923741
doi: 10.1016/j.ajoc.2020.100895
pii: S2451-9936(20)30210-3
pii: 100895
pmc: PMC7474402
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100895Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
None.
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