Plasma Androgen Receptor Copy Number Status at Emergence of Metastatic Castration-Resistant Prostate Cancer: A Pooled Multicohort Analysis.

Increases in androgen receptor ( PCR2023 was an international, multi-institution, open-label, phase II study of abiraterone acetate plus prednisolone (AAP) or abiraterone acetate plus dexamethasone that included plasma Using multivariable fractional polynomials analysis using Cox regression models, a nonlinear relationship between plasma Patients with metastatic castration-resistant prostate cancer can be dichotomized by a plasma

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© 2019 by American Society of Clinical Oncology.

Déclaration de conflit d'intérêts

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/po/author-center. Anna WingateResearch Funding: Janssen (Inst) Travel, Accommodations, Expenses: JanssenVincenza ConteducaConsulting or Advisory Role: Bayer, Astellas Pharma, Janssen-Cilag, Sanofi Travel, Accommodations, Expenses: Bayer, Astellas Pharma, Janssen-Cilag, SanofiDaniel KhalafConsulting or Advisory Role: BayerFabio CalabròConsulting or Advisory Role: PfizerSusan FeyerabendConsulting or Advisory Role: Janssen-CilagEnrique GrandeHonoraria: Pfizer, Bristol-Myers Squibb, Ipsen, Roche, Eisai, Eusa Pharma, MSD, Genzyme, Adacap, Novartis, Pierre Fabre, Lexicon, Celgene, Janssen-Cilag, Astellas Pharma Consulting or Advisory Role: MSD, Pfizer, Ipsen Research Funding: MTEM/Threshold (Inst), Roche, Pfizer (Inst), AstraZeneca (Inst), Ipsen (Inst) Travel, Accommodations, Expenses: Bristol-Myers Squibb, Genentech, Pfizer, Janssen-CilagAlfredo BerrutiConsulting or Advisory Role: Janssen-Cilag, Astellas Pharma Speakers' Bureau: Janssen-Cilag Research Funding: Astellas Pharma (Inst), Janssen-Cilag (Inst) Travel, Accommodations, Expenses: Janssen-Cilag, SanofiCora N. SternbergHonoraria: Pfizer, Astellas Pharma, Sanofi, Ipsen, AstraZeneca. Janssen Consulting or Advisory Role: Bristol-Myers Squibb, Novartis, Bayer, Eisai, MSD, Clovis Oncology, Pfizer, Roche, Ipsen, Incyte, AstraZeneca, Sanofi, Merck, Medscape, UroToday Research Funding: Janssen (Inst), Genentech (Inst), Bayer (Inst), Sanofi (Inst), Medivation (Inst), Exelixis (Inst), Genzyme (Inst), Aragon Pharmaceuticals (Inst), Array BioPharma (Inst), Aveo (Inst), AstraZeneca (Inst), Bristol-Myers Squibb (Inst), Boehringer Ingelheim (Inst), Clovis Oncology (Inst), Eisai (Inst), Genentech (Inst), GlaxoSmithKline (Inst), Eli Lilly (Inst), Incyte (Inst), Merck (Inst), Millennium (Inst), Myovant Sciences (Inst), Nektar (Inst), Pfizer (Inst), Clovis Atlas (Inst)Rob JonesHonoraria: Astellas Pharma, Janssen, AstraZeneca, MSD Oncology, Bristol-Myers Squibb, Pfizer, Novartis, Ipsen, Seattle Genetics, Sanofi, Bayer, Genentech, Eusa Pharma, Pharmacyclics Consulting or Advisory Role: Clovis Oncology Research Funding: Roche (Inst), Astellas Pharma (Inst), AstraZeneca (Inst), Pfizer (Inst), Novartis (Inst), Exelixis (Inst), Clovis Oncology (Inst) Travel, Accommodations, Expenses: Ipsen, Bayer, Janssen, Astellas Pharma, MSD OncologyFlorence LefresneEmployment: Johnson & Johnson Stock and Other Ownership Interests: Johnson & Johnson Honoraria: Johnson & Johnson Research Funding: Johnson & Johnson Travel, Accommodations, Expenses: Johnson & JohnsonMarjolein LahayeEmployment: Janssen-Cilag Leadership: Janssen-Cilag Stock and Other Ownership Interests: Janssen-Cilag Honoraria: Janssen-Cilag Consulting or Advisory Role: Janssen-CilagShibu ThomasEmployment: Janssen Research & Development Leadership: Janssen Research & Development Stock and Other Ownership Interests: Janssen Research & Development Research Funding: Janssen Oncology Patents, Royalties, Other Intellectual Property: Four patents (Inst) Travel, Accommodations, Expenses: Janssen Research & DevelopmentDong ShenEmployment: Janssen Research & Development Stock and Other Ownership Interests: Janssen Research & DevelopmentDeborah RicciEmployment: Janssen Stock and Other Ownership Interests: Janssen Patents, Royalties, Other Intellectual Property: Janssen (Inst) Travel, Accommodations, Expenses: JanssenMichael GormleyEmployment: Janssen Research & Development Stock and Other Ownership Interests: Johnson & Johnson Patents, Royalties, Other Intellectual Property: I have several patents pending where I am listed as the inventor of things that have been developed in the course of my work at Janssen Research and Development (Inst) Travel, Accommodations, Expenses: Janssen Research & DevelopmentAxel S. MerseburgerHonoraria: Janssen-Cilag, Astellas Pharma, Ipsen, Roche, Bristol-Myers Squibb, Eisai, Takeda, Pfizer, Novartis Consulting or Advisory Role: MSD Oncology, Bristol-Myers Squibb, Janssen-Cilag, Astellas Pharma, Ipsen Speakers' Bureau: Ipsen Research Funding: Novartis (Inst), AstraZeneca (Inst), Janssen-Cilag (Inst), Bristol-Myers Squibb (Inst), Clovis Oncology (Inst) Travel, Accommodations, Expenses: Janssen-Cilag, Astellas Pharma, IpsenBertrand TombalHonoraria: Amgen, Astellas Pharma, Bayer, Ferring, Sanofi, Janssen, Pfizer, Myovant Sciences Consulting or Advisory Role: Astellas Pharma, Bayer, Ferring, Janssen, Takeda, Steba Biotech, Sanofi Speakers' Bureau: Amgen, Janssen Research Funding: Ferring (Inst) Travel, Accommodations, Expenses: Amgen, Astellas Pharma, Bayer, Ferring, Janssen, SanofiKim N. ChiHonoraria: Sanofi, Janssen, Astellas Pharma, Bayer Consulting or Advisory Role: Essa, Astellas Pharma, Janssen, Sanofi, Amgen, Bayer, AstraZeneca, Roche Research Funding: Janssen (Inst), Astellas Pharma (Inst), Bayer (Inst), Sanofi (Inst), Tokai Pharmaceuticals (Inst), Eli Lilly/ImClone (Inst), Bristol-Myers Squibb (Inst), Merck (Inst), Roche (Inst)Ugo De GiorgiConsulting or Advisory Role: Pfizer, Janssen, Astellas Pharma, Sanofi, Bristol-Myers Squibb, Bayer, Ipsen, Merck Research Funding: Sanofi (Inst), AstraZeneca (Inst), Roche (Inst) Travel, Accommodations, Expenses: Bristol-Myers Squibb, Ipsen, Janssen, PfizerEnrique Gonzalez-BillalabeitiaTravel, Accommodations, Expenses: Bristol-Myers Squibb, Pfizer, Bristol-Myers Squibb, Janssen-Cilag, Astellas Pharma, Sanofi, Roche, PfizerAlexander W. WyattConsulting or Advisory Role: Genzyme Speakers' Bureau: Janssen Research Funding: JanssenGerhardt AttardHonoraria: Janssen, Astellas Pharma, Janssen (I) Consulting or Advisory Role: Janssen-Cilag, Veridex, Ventana Medical Systems, Astellas Pharma, Medivation, Novartis, Millennium, Abbott Laboratories, ESSA, Bayer, Pfizer Speakers' Bureau: Janssen, Astellas Pharma, Takeda, Sanofi, Ventana Medical Systems Research Funding: Janssen (Inst), Arno Therapeutics (Inst), Innocrin Pharma (Inst) Patents, Royalties, Other Intellectual Property: I am on the Institute of Cancer Research Rewards to Inventors list of abiraterone acetate Travel, Accommodations, Expenses: Janssen, Astellas Pharma, Medivation, Ventana Medical Systems, Abbott Laboratories, Bayer, ESSA, Janssen (I), Astellas Pharma (I), Pfizer Other Relationship: Institute of Cancer Research No other potential conflicts of interest were reported.