Endothelial connexins in vascular function.
connexin
endothelium
gap junction
intercellular communication
Journal
Vascular biology (Bristol, England)
ISSN: 2516-5658
Titre abrégé: Vasc Biol
Pays: England
ID NLM: 101763329
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
10
2019
accepted:
07
11
2019
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
15
9
2020
Statut:
epublish
Résumé
Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the synchronization of their behavior along the vascular tree. Gap junction channels are formed by connexins; six connexins form a connexon or hemichannel and the docking of two connexons result in a full gap junction channel allowing for the exchange of ions and small metabolites between neighboring cells. Recent evidence indicates that the intracellular domains of connexins may also function as an interaction platform (interactome) for other proteins, thereby regulating their function. Interestingly, fragments of Cx proteins generated by alternative internal translation were recently described, although their functions in the vascular wall remain to be uncovered. Variations in connexin expression are observed along different types of blood and lymphatic vessels; the most commonly found endothelial connexins are Cx37, Cx40, Cx43 and Cx47. Physiological studies on connexin-knockout mice demonstrated the essential roles of these channel-forming proteins in the coordination of vasomotor activity, endothelial permeability and inflammation, angiogenesis and in the maintenance of fluid balance in the body.
Identifiants
pubmed: 32923963
doi: 10.1530/VB-19-0015
pii: VB-19-0015
pmc: PMC7439941
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
H117-H124Informations de copyright
© 2019 The authors.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review.
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