Clinical utility of irx3 in keratoconus.

Corneal Topography Corneal Wavefront Aberration / diagnosis Homeodomain Proteins Humans Keratoconus / diagnosis Prospective Studies Reproducibility of Results Transcription Factors
Pentacam irx3 wavefront aberrometry keratoconus ocular aberrations vertical coma

Journal

Clinical & experimental optometry
ISSN: 1444-0938
Titre abrégé: Clin Exp Optom
Pays: United States
ID NLM: 8703442

Informations de publication

Date de publication:
Jan 2021
Historique:
pubmed: 15 9 2020
medline: 30 9 2021
entrez: 14 9 2020
Statut: ppublish

Résumé

Diagnosis and monitoring of keratoconus is increasingly being conducted with the aid of imaging equipment such as corneal aberrometry. There is a need to also know the confidence with which ocular aberration measurements can be made. To assess the repeatability of lower- and higher-order aberration measurements in patients with keratoconus using the irx3 wavefront aberrometer (Imagine Eyes, Orsay, France) and evaluate correlations with corneal curvature. The irx3 wavefront aberrometer was used to measure bilateral lower- and higher-order ocular aberrations on 33 participants with keratoconus. Three measurements were taken from each eye to determine the repeatability of lower-order aberrations (quantified as sphere and cylinder in dioptres) and higher-order aberration co-efficients (up to eighth order in micrometres), coma, trefoil and total higher-order aberration root mean square (in micrometres). Corneal curvature was measured using the Pentacam HR system (OCULUS, Wetzlar, Germany). Repeat measurements for lower-order aberrations resulted in larger co-efficients of repeatability than higher-order aberrations. Similarly, larger co-efficients of repeatability between repeated measures across all Zernike co-efficients were observed in eyes with severe keratoconus (that is, corneal curvature > 52-D) compared to eyes with flatter corneas. The difference between repeated measures tended to be significant for the lower-order aberrations regardless of corneal curvature. The highest correlations with corneal curvature for right and left eyes respectively, were identified for total higher-order aberration root mean square (r = 0.92, p < 0.001 and r = 0.91, p < 0.001), followed closely by coma (r = -0.93, p < 0.001 and r = -0.86, p < 0.001) and the Z (3, -1) co-efficient (r = -0.92, p < 0.001 and r = -0.86, p < 0.001 for right and left eyes, respectively). Lower-order aberrations tended to be less repeatable, indicating that instrument variability must be considered when monitoring progression. Total higher-order aberration root mean square and third-order aberrations, in particular the vertical coma Z (3, -1) co-efficient, demonstrated a stronger correlation with corneal curvature than the lower-order aberrations.

Sections du résumé

CLINICAL RELEVANCE CONCLUSIONS
Diagnosis and monitoring of keratoconus is increasingly being conducted with the aid of imaging equipment such as corneal aberrometry. There is a need to also know the confidence with which ocular aberration measurements can be made.
BACKGROUND BACKGROUND
To assess the repeatability of lower- and higher-order aberration measurements in patients with keratoconus using the irx3 wavefront aberrometer (Imagine Eyes, Orsay, France) and evaluate correlations with corneal curvature.
METHODS METHODS
The irx3 wavefront aberrometer was used to measure bilateral lower- and higher-order ocular aberrations on 33 participants with keratoconus. Three measurements were taken from each eye to determine the repeatability of lower-order aberrations (quantified as sphere and cylinder in dioptres) and higher-order aberration co-efficients (up to eighth order in micrometres), coma, trefoil and total higher-order aberration root mean square (in micrometres). Corneal curvature was measured using the Pentacam HR system (OCULUS, Wetzlar, Germany).
RESULTS RESULTS
Repeat measurements for lower-order aberrations resulted in larger co-efficients of repeatability than higher-order aberrations. Similarly, larger co-efficients of repeatability between repeated measures across all Zernike co-efficients were observed in eyes with severe keratoconus (that is, corneal curvature > 52-D) compared to eyes with flatter corneas. The difference between repeated measures tended to be significant for the lower-order aberrations regardless of corneal curvature. The highest correlations with corneal curvature for right and left eyes respectively, were identified for total higher-order aberration root mean square (r = 0.92, p < 0.001 and r = 0.91, p < 0.001), followed closely by coma (r = -0.93, p < 0.001 and r = -0.86, p < 0.001) and the Z (3, -1) co-efficient (r = -0.92, p < 0.001 and r = -0.86, p < 0.001 for right and left eyes, respectively).
CONCLUSIONS CONCLUSIONS
Lower-order aberrations tended to be less repeatable, indicating that instrument variability must be considered when monitoring progression. Total higher-order aberration root mean square and third-order aberrations, in particular the vertical coma Z (3, -1) co-efficient, demonstrated a stronger correlation with corneal curvature than the lower-order aberrations.

Identifiants

DOI: 10.1111/cxo.13133 PMID: 32924191
pubmed: 32924191
doi: 10.1111/cxo.13133
doi:

Substances chimiques

Homeodomain Proteins 0
IRX3 protein, human 0
Transcription Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

107-114

Subventions

Organisme : Guide Dogs NSW/ACT

Auteurs

Maria Markoulli (M)

School of Optometry and Vision Science, The University of New South Wales , Sydney, Australia.
ORCID: 0000-0002-9227-5866

Cathleen Fedtke (C)

School of Optometry and Vision Science, The University of New South Wales , Sydney, Australia.

Minas Coroneo (M)

Department of Ophthalmology, Prince of Wales Clinical School, Faculty of Medicine, The University of New South Wales , Sydney, Australia.

Michael Kalloniatis (M)

School of Optometry and Vision Science, The University of New South Wales , Sydney, Australia.
Centre for Eye Health, The University of New South Wales , Sydney, Australia.
ORCID: 0000-0002-5264-4639

Andrew Whatham (A)

Centre for Eye Health, The University of New South Wales , Sydney, Australia.

Michael Yapp (M)

Centre for Eye Health, The University of New South Wales , Sydney, Australia.

Barbara Zangerl (B)

School of Optometry and Vision Science, The University of New South Wales , Sydney, Australia.
Centre for Eye Health, The University of New South Wales , Sydney, Australia.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic ophtalmologique › Topographie cornéenne › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Maladies de l'oeil › Troubles de la réfraction oculaire › Aberration du front d'onde cornéen › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Maladies de l'oeil › Maladies de la cornée › Kératocône › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Clinical utility of irx3 in keratoconus.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Clinical utility of irx3 in keratoconus.