Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of

Anti-Bacterial Agents / chemistry Biofilms / drug effects Carbohydrates / chemistry Cell Line, Tumor Ciprofloxacin / chemistry Dose-Response Relationship, Drug HEK293 Cells Humans Lectins / antagonists & inhibitors Molecular Structure Pseudomonas aeruginosa / drug effects Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 10 2020
Historique:
pubmed: 15 9 2020
medline: 19 12 2020
entrez: 14 9 2020
Statut: ppublish

Résumé

Chronic infections by

Identifiants

DOI: 10.1021/acs.jmedchem.0c00856 PMID: 32924479 PMC: PMC7586336
pubmed: 32924479
doi: 10.1021/acs.jmedchem.0c00856
pmc: PMC7586336
doi:

Substances chimiques

Anti-Bacterial Agents 0
Carbohydrates 0
Lectins 0
Ciprofloxacin 5E8K9I0O4U

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11707-11724

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Auteurs

Joscha Meiers (J)

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.
Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.
Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany.

Eva Zahorska (E)

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.
Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.
Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany.

Teresa Röhrig (T)

Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.
Drug Design and Optimization (DDOP), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.

Dirk Hauck (D)

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.
Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.

Stefanie Wagner (S)

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.
Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.

Alexander Titz (A)

Chemical Biology of Carbohydrates (CBCH), Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, D-66123 Saarbrücken, Germany.
Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, D-38124 Braunschweig, Germany.
Department of Pharmacy and Department of Chemistry, Saarland University, D-66123 Saarbrücken, Germany.
ORCID: 0000-0001-7408-5084

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Directing Drugs to Bugs:...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Directing Drugs to Bugs:...
questionsmedicales.fr › Glucides › Directing Drugs to Bugs:...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Directing Drugs to Bugs:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Ciprofloxacine › Directing Drugs to Bugs:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Directing Drugs to Bugs:...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Directing Drugs to Bugs:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Directing Drugs to Bugs:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Directing Drugs to Bugs:...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Directing Drugs to Bugs:...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Directing Drugs to Bugs:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Directing Drugs to Bugs:...