Predicting Mental Decline Rates in Mild Cognitive Impairment From Baseline MRI Volumetric Data.
Aged
Alzheimer Disease
/ classification
Atrophy
/ pathology
Brain
/ pathology
Cognitive Dysfunction
/ classification
Disease Progression
Entorhinal Cortex
/ pathology
Female
Hippocampus
/ pathology
Humans
Magnetic Resonance Imaging
/ statistics & numerical data
Male
Mental Status and Dementia Tests
/ statistics & numerical data
Retrospective Studies
Journal
Alzheimer disease and associated disorders
ISSN: 1546-4156
Titre abrégé: Alzheimer Dis Assoc Disord
Pays: United States
ID NLM: 8704771
Informations de publication
Date de publication:
Historique:
received:
03
04
2020
accepted:
08
08
2020
pubmed:
15
9
2020
medline:
7
10
2021
entrez:
14
9
2020
Statut:
ppublish
Résumé
In mild cognitive impairment (MCI), identifying individuals at high risk for progressive cognitive deterioration can be useful for prognostication and intervention. This study quantitatively characterizes cognitive decline rates in MCI and tests whether volumetric data from baseline magnetic resonance imaging (MRI) can predict accelerated cognitive decline. The authors retrospectively examined Alzheimer Disease Neuroimaging Initiative data to obtain serial Mini-Mental Status Exam (MMSE) scores, diagnoses, and the following baseline MRI volumes: total intracranial volume, whole-brain and ventricular volumes, and volumes of the hippocampus, entorhinal cortex, fusiform gyrus, and medial temporal lobe. Subjects with <24 months or <4 measurements of MMSE data were excluded. Predictive modeling of fast cognitive decline (defined as >0.6/year) from baseline volumetric data was performed on subjects with MCI using a single hidden layer neural network. Among 698 baseline MCI subjects, the median annual decline in the MMSE score was 1.3 for converters to dementia versus 0.11 for stable MCI (P<0.001). A 0.6/year threshold captured dementia conversion with 82% accuracy (sensitivity 79%, specificity 85%, area under the receiver operating characteristic curve 0.88). Regional volumes on baseline MRI predicted fast cognitive decline with a test accuracy of 71%. An MMSE score decrease of >0.6/year is associated with MCI-to-dementia conversion and can be predicted from baseline MRI.
Identifiants
pubmed: 32925201
pii: 00002093-202101000-00001
doi: 10.1097/WAD.0000000000000406
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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