Solitary Fibrous Tumor of the Vulva: Case Report of a Rare Entity and Review of Literature.
Biomarkers, Tumor
/ genetics
Cell Nucleus
/ metabolism
Diagnosis, Differential
Female
Hemangiopericytoma
/ diagnosis
Humans
Immunohistochemistry
Middle Aged
Repressor Proteins
/ genetics
STAT6 Transcription Factor
/ genetics
Solitary Fibrous Tumors
/ diagnosis
Vulva
/ pathology
Vulvar Neoplasms
/ diagnosis
Journal
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
ISSN: 1538-7151
Titre abrégé: Int J Gynecol Pathol
Pays: United States
ID NLM: 8214845
Informations de publication
Date de publication:
01 May 2021
01 May 2021
Historique:
pubmed:
15
9
2020
medline:
9
11
2021
entrez:
14
9
2020
Statut:
ppublish
Résumé
Solitary fibrous tumor (SFT) is an uncommon mesenchymal tumor of fibroblastic origin, which shows a prominent hemangiopericytoma-like branching pattern. It may be found at any location and can rarely involve the female genital tract with the vulva being the most common site of involvement. This is a case report of vulvar SFT in a 47-yr-old female who presented with a slow growing vulvar mass for 3 yr. Histologic examination showed a neoplasm composed of ovoid to spindle shaped cells with hypocellular and hypercellular areas in a collagenous background. Prominent hemangiopericytoma-like vessels were identified. Immunohistochemistry showed positive staining of the tumor cells for CD34, STAT6, ER, PR, and vimentin. Immunoshistochemical staining for desmin, SMA, and S100 was negative. The majority of SFTs have a NAB2-STAT6 gene fusion on chromosome 12, resulting in nuclear STAT6 overexpression, which is a sensitive and specific immunohistochemical marker for its diagnosis. Only 25 cases of vulvar SFT have been reported in the English literature and it should be considered in the differential diagnosis of spindle cell lesions at this site.
Identifiants
pubmed: 32925444
pii: 00004347-202105000-00005
doi: 10.1097/PGP.0000000000000707
doi:
Substances chimiques
Biomarkers, Tumor
0
NAB2 protein, human
0
Repressor Proteins
0
STAT6 Transcription Factor
0
STAT6 protein, human
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-239Informations de copyright
Copyright © 2020 by the International Society of Gynecological Pathologists.
Déclaration de conflit d'intérêts
The author declares no conflict of interest.
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