Differences in Bone Mineral Density and Bone Turnover Markers Between Subjects With and Without Diffuse Idiopathic Skeletal Hyperostosis.
Journal
Spine
ISSN: 1528-1159
Titre abrégé: Spine (Phila Pa 1976)
Pays: United States
ID NLM: 7610646
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
pubmed:
15
9
2020
medline:
16
2
2021
entrez:
14
9
2020
Statut:
ppublish
Résumé
Japanese resident cohort study based on a municipal registry. This study of a community-dwelling elderly Japanese population employed random sampling from the basic resident registry of a rural town for subject selection to investigate the differences in bone mineral density (BMD) and bone turnover markers between subjects with and without diffuse idiopathic skeletal hyperostosis (DISH). DISH is a condition characterized by the calcification and ossification of soft tissues. Although some reports have addressed BMD in DISH, the precise status of BMD and bone metabolism in individuals with DISH remains unclear. Eight groups based on age (50s, 60s, 70s, and 80s) and sex after random sampling from the resident registry of Obuse town were established. A total of 411 participants (202 males and 209 females) were enrolled for the evaluation of BMD and bone turnover markers. All subjects underwent a single whole-spine lateral radiographic examination for the existence of DISH. The BMD and bone turnover markers of subjects with and without DISH were analyzed for associations with the disorder using multivariate analysis. DISH was detected in 66 (16.1%) participants in our population cohort. According to multivariate analysis, increased lumbar and hip BMD were significantly related to DISH (odds ratio: 7.47 and 22.8, respectively). This study clarified the differences in BMD and bone turnover markers between subjects with and without DISH on a general population basis. Multivariate analysis revealed increased lumbar and hip BMD to be significantly associated with DISH, with no remarkable findings for bone turnover markers. 4.
Sections du résumé
STUDY DESIGN
METHODS
Japanese resident cohort study based on a municipal registry.
OBJECTIVE
OBJECTIVE
This study of a community-dwelling elderly Japanese population employed random sampling from the basic resident registry of a rural town for subject selection to investigate the differences in bone mineral density (BMD) and bone turnover markers between subjects with and without diffuse idiopathic skeletal hyperostosis (DISH).
SUMMARY OF BACKGROUND DATA
BACKGROUND
DISH is a condition characterized by the calcification and ossification of soft tissues. Although some reports have addressed BMD in DISH, the precise status of BMD and bone metabolism in individuals with DISH remains unclear.
METHODS
METHODS
Eight groups based on age (50s, 60s, 70s, and 80s) and sex after random sampling from the resident registry of Obuse town were established. A total of 411 participants (202 males and 209 females) were enrolled for the evaluation of BMD and bone turnover markers. All subjects underwent a single whole-spine lateral radiographic examination for the existence of DISH. The BMD and bone turnover markers of subjects with and without DISH were analyzed for associations with the disorder using multivariate analysis.
RESULTS
RESULTS
DISH was detected in 66 (16.1%) participants in our population cohort. According to multivariate analysis, increased lumbar and hip BMD were significantly related to DISH (odds ratio: 7.47 and 22.8, respectively).
CONCLUSION
CONCLUSIONS
This study clarified the differences in BMD and bone turnover markers between subjects with and without DISH on a general population basis. Multivariate analysis revealed increased lumbar and hip BMD to be significantly associated with DISH, with no remarkable findings for bone turnover markers.
LEVEL OF EVIDENCE
METHODS
4.
Identifiants
pubmed: 32925682
doi: 10.1097/BRS.0000000000003689
pii: 00007632-202012150-00014
doi:
Substances chimiques
Biomarkers
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1677-E1681Références
Forestier J, Lagier R. Ankylosing hyperostosis of the spine. Clin Orthop 1971; 74:65–83.
Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 1976; 119:559–568.
Mader R. Clinical manifestations of diffuse idiopathic skeletal hyperostosis of the cervical spine. Semin Arthritis Rheum 2002; 32:130–135.
Diederichs G, Engelken F, Marshall LM, et al. Diffuse idiopathic skeletal hyperostosis (DISH): relation to vertebral fractures and bone density. Osteoporos Int 2011; 22:1789–1797.
Kuperus JS, Samsour L, Buckens CF, et al. Bone mineral density changes over time in diffuse idiopathic skeletal hyperostosis of the thoracic spine. Bone 2018; 112:90–96.
Westerveld LA, Verlaan JJ, Lam MG, et al. The influence of diffuse idiopathic skeletal hyperostosis on bone mineral density measurements of the spine. Rheumatology (Oxford) 2009; 48:1133–1136.
Uehara M, Takahashi J, Ikegami S, et al. Sagittal spinal alignment deviation in the general elderly population: A Japanese cohort survey randomly sampled from a basic resident registry. Spine J 2019; 19:349–356.
Tokida R, Uehara M, Ikegami S, et al. The association between sagittal spinal alignment and physical function in a Japanese cohort sampled from an older general population: a Japanese cohort survey randomly sampled from a basic resident registry. J Bone Joint Surg Am 2019; 101:1698–1706.
Uehara M, Takahashi J, Ikegami S, et al. Impact of diffuse idiopathic skeletal hyperostosis on sagittal spinal alignment in the general elderly population: a Japanese cohort survey randomly sampled from a basic resident registry. JBJS Open Access 2019; 4:1–6.
Uehara M, Takahashi J, Ikegami S, et al. Prevalence of diffuse idiopathic skeletal hyperostosis in the general elderly population: a Japanese cohort survey randomly sampled from a basic resident registry. Clin Spine Surg 2020; 33:123–127.
Cassim B, Mody GM, Rubin DL. The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. Br J Rheumatol 1990; 29:131–132.
Kim SK, Choi BR, Kim CG, et al. The prevalence of diffuse idiopathic skeletal hyperostosis in Korea. J Rheumatol 2004; 31:2032–2035.
Weinfeld RM, Olson PN, Maki DD, et al. The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in two large American Midwest metropolitan hospital populations. Skeletal Radiol 1997; 26:222–225.
Holten KF, Denard PJ, Yoo JU, et al. Diffuse idiopathic skeletal hyperostosis and its relation to back pain among older men: the MrOS study. Semin Arthritis Rheum 2011; 41:131–138.
Littlejohn GO. Insulin and new bone formation in diffuse idiopathic skeletal hyperostosis. Clin Rheumatol 1985; 4:294–300.
Vezyroglou G, Mitropoulos A, Kyriazis N, et al. A metabolic syndrome in diffuse idiopathic skeletal hyperostosis: a controlled study. J Rheumatol 1996; 23:672–676.
Laroche M, Moulinier L, Arlet J, et al. Lumbar and cervical stenosis. Frequency of the association, role of the ankylosing hyperostosis. Clin Rheumatol 1992; 11:533–535.
Sarzi-Puttini AF. New developments in our understanding of DISH (diffuse idiopathic skeletal hyperostosis). Curr Opin Rheumatol 2004; 16:287–292.
Sencan D, Elden H, Nacitrahan V, et al. The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus. Rheumatol Int 1995; 25:518–521.
Kagotani R, Yoshida M, Muraki S, et al. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. J Bone Miner Metab 2015; 33:221–229.
Hiyama A, Katoh H, Sakai D, et al. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects. BMC Musculoskelet Disord 2018; 19:178.
Sahin G, Polat G, Bagis S, et al. Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus. J Womens Health (Larchmt) 2002; 11:801–804.
Banno T, Togawa D, Hasegawa T, et al. The controlled study of diffuse idiopathic skeletal hyperostosis for the assessment of physical function in elderly population. J Orthop Sci 2018; 23:929–934.
Niu CC, Lin SS, Yuan LJ, et al. Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL. BMC Musculoskelet Disord 2017; 18:61.