Effectiveness of

Arthralgia / drug therapy Curcuma Double-Blind Method Female Humans Knee Joint / diagnostic imaging Magnetic Resonance Imaging Male Middle Aged Osteoarthritis, Knee / complications Pain Measurement Phytotherapy / methods Plant Extracts / therapeutic use Synovitis / drug therapy Ultrasonography

Journal

Annals of internal medicine
ISSN: 1539-3704
Titre abrégé: Ann Intern Med
Pays: United States
ID NLM: 0372351

Informations de publication

Date de publication:
01 12 2020
Historique:
pubmed: 15 9 2020
medline: 5 1 2021
entrez: 14 9 2020
Statut: ppublish

Résumé

Current pharmacologic therapies for patients with osteoarthritis are suboptimal. To determine the efficacy of Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224). Single-center study with patients from southern Tasmania, Australia. 70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis. 2 capsules of CL ( The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and cartilage composition values. Outcomes were assessed over 12 weeks. CL improved VAS pain compared with placebo by -9.1 mm (95% CI, -17.8 to -0.4 mm [ Modest sample size and short duration. CL was more effective than placebo for knee pain but did not affect knee effusion-synovitis or cartilage composition. Multicenter trials with larger sample sizes are needed to assess the clinical significance of these findings. University of Tasmania and Natural Remedies Private Limited.

Sections du résumé

BACKGROUND
Current pharmacologic therapies for patients with osteoarthritis are suboptimal.
OBJECTIVE
To determine the efficacy of
DESIGN
Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224).
SETTING
Single-center study with patients from southern Tasmania, Australia.
PARTICIPANTS
70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion-synovitis.
INTERVENTION
2 capsules of CL (
MEASUREMENTS
The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion-synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and cartilage composition values. Outcomes were assessed over 12 weeks.
RESULTS
CL improved VAS pain compared with placebo by -9.1 mm (95% CI, -17.8 to -0.4 mm [
LIMITATION
Modest sample size and short duration.
CONCLUSION
CL was more effective than placebo for knee pain but did not affect knee effusion-synovitis or cartilage composition. Multicenter trials with larger sample sizes are needed to assess the clinical significance of these findings.
PRIMARY FUNDING SOURCE
University of Tasmania and Natural Remedies Private Limited.

Identifiants

DOI: 10.7326/M20-0990 PMID: 32926799
pubmed: 32926799
doi: 10.7326/M20-0990
doi:

Substances chimiques

Plant Extracts 0
turmeric extract 856YO1Z64F

Banques de données

ANZCTR
['ACTRN12618000080224']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

861-869

Auteurs

Zhiqiang Wang (Z)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).
ORCID: 0000-0002-8087-436X

Graeme Jones (G)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).

Tania Winzenberg (T)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).
ORCID: 0000-0002-4112-3491

Guoqi Cai (G)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).

Laura L Laslett (LL)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).
ORCID: 0000-0002-4336-0095

Dawn Aitken (D)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).
ORCID: 0000-0001-5685-7634

Ingrid Hopper (I)

Monash University, Melbourne, Victoria, Australia (I.H.).

Ambrish Singh (A)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).
ORCID: 0000-0002-4618-7507

Robert Jones (R)

Royal Hobart Hospital, Hobart, Tasmania, Australia (R.J.).

Jurgen Fripp (J)

University of Queensland, Brisbane, Queensland, Australia (J.F.).

Changhai Ding (C)

University of Tasmania, Hobart, Tasmania, Australia, and Southern Medical University, Guangzhou, China (C.D.).

Benny Antony (B)

University of Tasmania, Hobart, Tasmania, Australia (Z.W., G.J., T.W., G.C., L.L.L., D.A., A.S., B.A.).

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Arthralgie › Effectiveness of
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Zingiberales › Zingiberaceae › Curcuma › Effectiveness of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en double aveugle › Effectiveness of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effectiveness of
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Articulation du genou › Effectiveness of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Effectiveness of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effectiveness of
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Gonarthrose › Effectiveness of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Examen physique › Examen neurologique › Mesure de la douleur › Effectiveness of
questionsmedicales.fr › Thérapeutique › Thérapies complémentaires › Phytothérapie › Effectiveness of
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Effectiveness of
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Synovite › Effectiveness of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Échographie › Effectiveness of