Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression.

Chemokines Cytokines Depressive Disorder / diagnosis Humans Interleukin-8 Retrospective Studies
Depression IL-8 Interleukin 8 Neuroinflammation

Journal

Comprehensive psychiatry
ISSN: 1532-8384
Titre abrégé: Compr Psychiatry
Pays: United States
ID NLM: 0372612

Informations de publication

Date de publication:
10 2020
Historique:
received: 30 01 2020
revised: 05 07 2020
accepted: 17 07 2020
pubmed: 15 9 2020
medline: 22 12 2020
entrez: 14 9 2020
Statut: ppublish

Résumé

Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression. Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay. IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001). The significance of the results is limited by the retrospective design and methodological aspects. The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression.

Identifiants

DOI: 10.1016/j.comppsych.2020.152196 PMID: 32927367
pubmed: 32927367
pii: S0010-440X(20)30038-9
doi: 10.1016/j.comppsych.2020.152196
pii:
doi:

Substances chimiques

Chemokines 0
Cytokines 0
Interleukin-8 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

152196

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interests HK: None. BLF: None. NMY: None. SWS: None. CZ: None. KN: None. SJM: None. PS: None. KR: None. MM: None. RD: None. BB: Received travel grants and/or training expenses from Bayer Vital GmbH, Ipsen Pharma GmbH, Norvartis, Biogen GmbH and Genzyme, as well as lecture fees from Ipsen Pharma GmbH, Alexion Pharma GmbH, Merck, Sanofi Genzyme and Roche. TR: None. NV: None. FK: None. TB: None. KD: Steering Committee Neurosciences, Janssen. LTvE: Advisory boards, lectures, or travel grants within the last three years: Roche, Eli Lilly, Janssen-Cilag, Novartis, Shire, UCB, GSK, Servier, Janssen and Cyberonics. DE: None.

Auteurs

Hanna Kuzior (H)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Bernd L Fiebich (BL)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Nizar M Yousif (NM)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Soraya W Saliba (SW)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Christiane Ziegler (C)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Kathrin Nickel (K)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Simon J Maier (SJ)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Patrick Süß (P)

Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany.

Kimon Runge (K)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Miriam Matysik (M)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Rick Dersch (R)

Department for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Benjamin Berger (B)

Department for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Tilman Robinson (T)

Department for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Nils Venhoff (N)

Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Franziska Kessler (F)

Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Thomas Blank (T)

Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Katharina Domschke (K)

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Germany.

Ludger Tebartz van Elst (L)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Dominique Endres (D)

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: dominique.endres@uniklinik-freiburg.de.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Increased IL-8 concentrations in the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Increased IL-8 concentrations in the...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Increased IL-8 concentrations in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased IL-8 concentrations in the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-8 › Increased IL-8 concentrations in the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Increased IL-8 concentrations in the...