Metabolism Regulation and Redox State: Insight into the Role of Superoxide Dismutase 1.
Amyotrophic Lateral Sclerosis
/ genetics
Animals
Antioxidants
/ metabolism
Cell Respiration
Cholesterol
/ metabolism
Diet
Energy Metabolism
Humans
Lymphocyte Activation
Mitochondria
/ metabolism
Reactive Oxygen Species
/ metabolism
Superoxide Dismutase-1
/ genetics
TOR Serine-Threonine Kinases
/ metabolism
amyotrophic lateral sclerosis
cholesterol metabolism
metabolism
mitochondria
reactive oxygen species
redox signaling
superoxide dismutase 1
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
05
08
2020
revised:
31
08
2020
accepted:
08
09
2020
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Energy metabolism and redox state are strictly linked; energy metabolism is a source of reactive oxygen species (ROS) that, in turn, regulate the flux of metabolic pathways. Moreover, to assure redox homeostasis, metabolic pathways and antioxidant systems are often coordinately regulated. Several findings show that superoxide dismutase 1 (SOD1) enzyme has effects that go beyond its superoxide dismutase activity and that its functions are not limited to the intracellular compartment. Indeed, SOD1 is secreted through unconventional secretory pathways, carries out paracrine functions and circulates in the blood bound to lipoproteins. Striking experimental evidence links SOD1 to the redox regulation of metabolism. Important clues are provided by the systemic effects on energy metabolism observed in mutant SOD1-mediated amyotrophic lateral sclerosis (ALS). The purpose of this review is to analyze in detail the involvement of SOD1 in redox regulation of metabolism, nutrient sensing, cholesterol metabolism and regulation of mitochondrial respiration. The scientific literature on the relationship between ALS, mutated SOD1 and metabolism will also be explored, in order to highlight the metabolic functions of SOD1 whose biological role still presents numerous unexplored aspects that deserve further investigation.
Identifiants
pubmed: 32927603
pii: ijms21186606
doi: 10.3390/ijms21186606
pmc: PMC7554782
pii:
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Cholesterol
97C5T2UQ7J
Superoxide Dismutase-1
EC 1.15.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
FEBS Lett. 2005 Aug 29;579(21):4911-7
pubmed: 16111680
J Neurochem. 2002 Nov;83(3):535-45
pubmed: 12390515
FEBS Lett. 2015 Feb 13;589(4):432-9
pubmed: 25592834
J Biol Chem. 1969 Nov 25;244(22):6049-55
pubmed: 5389100
Mol Cell Neurosci. 2013 Jan;52:31-7
pubmed: 23147108
Neuron. 2004 Jul 8;43(1):19-30
pubmed: 15233914
Arch Biochem Biophys. 2017 Mar 1;617:94-100
pubmed: 27769838
J Immunol. 1996 Sep 15;157(6):2395-402
pubmed: 8805638
Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383
pubmed: 32231263
J Cell Physiol. 2012 Aug;227(8):3111-5
pubmed: 22015651
Immunology. 1988 Mar;63(3):431-7
pubmed: 3258279
Front Neurosci. 2018 Jan 24;12:10
pubmed: 29416499
J Neurosci. 2005 Jan 5;25(1):164-72
pubmed: 15634778
Front Cell Neurosci. 2016 Jun 02;10:146
pubmed: 27313511
Free Radic Biol Med. 2015 Nov;88(Pt B):108-146
pubmed: 26122708
Biochem J. 2013 Sep 1;454(2):249-57
pubmed: 23767918
J Cell Sci. 2012 Feb 15;125(Pt 4):801-6
pubmed: 22448036
Swiss Med Wkly. 2012 Aug 17;142:w13659
pubmed: 22903797
J Neurosci. 2008 Jul 9;28(28):7202-8
pubmed: 18614690
Neural Regen Res. 2014 Oct 1;9(19):1770-8
pubmed: 25422638
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):317-323
pubmed: 28962897
Cardiovasc Res. 2009 May 1;82(2):333-40
pubmed: 19050010
Free Radic Res. 2017 Apr;51(4):439-447
pubmed: 28412863
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11159-64
pubmed: 15263088
J Neurochem. 2007 Aug;102(3):679-85
pubmed: 17403136
Int J Stroke. 2018 Aug;13(6):612-632
pubmed: 29786478
Annu Rev Cell Dev Biol. 2011;27:441-64
pubmed: 21985671
Neurodegener Dis. 2015;15(2):109-13
pubmed: 25720304
Cell Calcium. 2007 Jul;42(1):59-69
pubmed: 17241659
Free Radic Biol Med. 2011 Jun 1;50(11):1591-8
pubmed: 21397007
Oxid Med Cell Longev. 2016;2016:4350965
pubmed: 26998193
Front Physiol. 2016 Nov 29;7:594
pubmed: 27965593
Glia. 2017 Apr;65(4):592-605
pubmed: 28139855
Mol Cell. 2008 Apr 25;30(2):214-26
pubmed: 18439900
Nat Rev Neurosci. 2013 Apr;14(4):248-64
pubmed: 23463272
Lancet Neurol. 2019 Feb;18(2):211-220
pubmed: 30663610
Redox Biol. 2020 May;32:101507
pubmed: 32208164
IUBMB Life. 2000 May;49(5):381-9
pubmed: 10902569
Curr Biol. 2007 Oct 9;17(19):1646-56
pubmed: 17900900
Tumour Biol. 2016 May;37(5):6661-71
pubmed: 26646563
Pharmacol Ther. 2009 May;122(2):97-108
pubmed: 19285105
Annu Rev Genet. 2008;42:27-81
pubmed: 18303986
Oxid Med Cell Longev. 2016;2016:1245049
pubmed: 27478531
Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):365-74
pubmed: 16677083
Neurology. 2008 Mar 25;70(13):1004-9
pubmed: 18199832
Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34
pubmed: 21952300
Mech Ageing Dev. 2010 Jul-Aug;131(7-8):517-26
pubmed: 20493207
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Nature. 1993 Mar 4;362(6415):59-62
pubmed: 8446170
Nat Immunol. 2004 Aug;5(8):818-27
pubmed: 15258578
Cell Metab. 2013 Apr 2;17(4):491-506
pubmed: 23562075
Redox Biol. 2014 Feb 23;2:535-62
pubmed: 24634836
Nat Commun. 2013;4:2139
pubmed: 23842546
Free Radic Biol Med. 1998 Sep;25(4-5):392-403
pubmed: 9741578
Free Radic Biol Med. 1999 Jan;26(1-2):14-24
pubmed: 9890636
Cancer Res. 2007 Apr 1;67(7):3043-53
pubmed: 17409411
PLoS One. 2010 Sep 20;5(9):
pubmed: 20862213
Trends Immunol. 2018 Jul;39(7):562-576
pubmed: 29739666
Trends Immunol. 2010 Jul;31(7):278-87
pubmed: 20579935
Cell Metab. 2018 Feb 6;27(2):299-313
pubmed: 29153408
Cell. 1997 Oct 17;91(2):231-41
pubmed: 9346240
J Biol Chem. 2012 Aug 24;287(35):29579-88
pubmed: 22773877
Adv Enzyme Regul. 1989;28:65-77
pubmed: 2624176
Biochim Biophys Acta. 2014 Aug;1842(8):1295-301
pubmed: 24568860
J Nutr. 2006 Jan;136(1 Suppl):319S-23S
pubmed: 16365106
Mol Cell. 2018 May 3;70(3):502-515.e8
pubmed: 29727620
Brain Res Bull. 1998 Mar 15;45(5):517-20
pubmed: 9570722
Nature. 2012 May 09;485(7400):661-5
pubmed: 22660331
Immunity. 2013 Feb 21;38(2):225-36
pubmed: 23415911
FEBS Lett. 2000 Feb 4;467(1):57-60
pubmed: 10664456
Int J Biol Macromol. 2020 Jun 15;153:600-607
pubmed: 32165203
Biochim Biophys Acta. 2014 Feb;1843(2):265-74
pubmed: 24184207
Physiol Rev. 2007 Jan;87(1):245-313
pubmed: 17237347
Brain Res Bull. 2015 Sep;118:1-6
pubmed: 26327496
Ann N Y Acad Sci. 2010 Aug;1203:45-52
pubmed: 20716282
Science. 2008 Jun 13;320(5882):1496-501
pubmed: 18497260
Biochem Biophys Res Commun. 2001 Sep 14;287(1):92-7
pubmed: 11549258
Int J Biochem Cell Biol. 2015 Mar;60:8-18
pubmed: 25562511
J Neurochem. 2006 Mar;96(5):1349-61
pubmed: 16478527
Mol Cell. 2011 Jan 21;41(2):139-49
pubmed: 21255725
Ann Neurol. 2019 Apr;85(4):470-481
pubmed: 30723964
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7634-8
pubmed: 6961438
Front Neurosci. 2015 Feb 24;9:56
pubmed: 25759638
Front Neurol. 2016 Mar 29;7:47
pubmed: 27065942
Free Radic Biol Med. 2002 Dec 1;33(11):1451-64
pubmed: 12446202
Cell Rep. 2017 Oct 3;21(1):1-9
pubmed: 28978464
Eur J Neurol. 2013 Apr;20(4):647-54
pubmed: 23094606
Mol Cell Biochem. 2002 Nov;240(1-2):47-55
pubmed: 12487371
Biochem Biophys Res Commun. 2002 Jul 19;295(3):603-9
pubmed: 12099681
Front Physiol. 2018 May 24;9:611
pubmed: 29881358
Mol Cell Biol. 2017 Sep 26;37(20):
pubmed: 28739857
J Cell Biol. 2017 Aug 9;216(9):2691-2700
pubmed: 28794127
Annu Rev Nutr. 2015;35:321-48
pubmed: 26185979
J Lipid Res. 1980 Jul;21(5):505-17
pubmed: 6995544
Cell Metab. 2007 Oct;6(4):280-93
pubmed: 17908557
Trends Immunol. 2018 Jun;39(6):489-502
pubmed: 29452982
Neuron. 2004 Jul 8;43(1):5-17
pubmed: 15233913
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62
pubmed: 22436748
Biochim Biophys Acta. 2006 Aug;1758(8):994-1003
pubmed: 16566894
Oxid Med Cell Longev. 2019 Jul 4;2019:4683723
pubmed: 31354906
J Cell Biol. 2013 Nov 25;203(4):563-74
pubmed: 24385483
J Biol Chem. 2005 Apr 8;280(14):13560-7
pubmed: 15653680
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Front Cell Neurosci. 2015 Jul 01;9:248
pubmed: 26190973
Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E165-71
pubmed: 17374702
J Biol Chem. 2000 Jul 28;275(30):23227-33
pubmed: 10806195
Cell Metab. 2010 Dec 1;12(6):662-7
pubmed: 21109198
Science. 2006 Jun 30;312(5782):1882-3
pubmed: 16809515
Nature. 2014 Sep 18;513(7518):440-3
pubmed: 25043031
Front Physiol. 2015 Jul 07;6:194
pubmed: 26217233
Chem Res Toxicol. 2004 Oct;17(10):1377-84
pubmed: 15487899
J Neurosci. 2005 Jan 5;25(1):108-17
pubmed: 15634772
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1563-72
pubmed: 16987011
Biochem Biophys Res Commun. 2004 Nov 12;324(2):887-92
pubmed: 15474511
J Biol Chem. 1973 Jul 10;248(13):4793-6
pubmed: 4578091
Mol Nutr Food Res. 2020 Jul;64(13):e1900999
pubmed: 32383217
Histochem Cell Biol. 2002 Aug;118(2):163-9
pubmed: 12189519
Curr Opin Cell Biol. 2008 Dec;20(6):678-87
pubmed: 18930818
Int J Biochem Cell Biol. 1996 Jun;28(6):677-81
pubmed: 8673732
Free Radic Biol Med. 2007 Aug 1;43(3):319-31
pubmed: 17602947
IUBMB Life. 2005 Jun;57(6):407-12
pubmed: 16012049
Science. 2010 Feb 19;327(5968):1000-4
pubmed: 20167786
Science. 2006 May 12;312(5775):927-30
pubmed: 16690869
Hum Mol Genet. 2013 Oct 1;22(19):3947-59
pubmed: 23736301
Cell Metab. 2008 Feb;7(2):104-12
pubmed: 18249170
Sci Rep. 2019 Dec 23;9(1):19652
pubmed: 31873138
Cell. 2003 Nov 26;115(5):577-90
pubmed: 14651849
Int J Mol Sci. 2019 Aug 05;20(15):
pubmed: 31387214
J Biol Chem. 2014 Feb 28;289(9):5412-6
pubmed: 24448804
Gene Expr. 2004;12(1):29-38
pubmed: 15473258
FASEB J. 2003 Nov;17(14):2091-3
pubmed: 14500553
N Engl J Med. 2007 Sep 27;357(13):1301-10
pubmed: 17898099
Free Radic Biol Med. 2008 Mar 15;44(6):938-55
pubmed: 18164271
Endocrinology. 2009 Oct;150(10):4541-51
pubmed: 19628573
J Cell Biol. 2013 Apr 15;201(2):293-308
pubmed: 23569215
Neurosci Lett. 2007 Nov 20;428(1):43-6
pubmed: 17942226
Lancet Neurol. 2011 Jan;10(1):75-82
pubmed: 21035400
Genes Dev. 2004 Oct 15;18(20):2491-505
pubmed: 15466158
Aging Cell. 2009 Apr;8(2):113-27
pubmed: 19239417
Cell Death Dis. 2016 Jun 09;7(6):e2253
pubmed: 27277675
J Neurosci. 1998 May 1;18(9):3241-50
pubmed: 9547233
Redox Biol. 2015 Dec;6:260-271
pubmed: 26296072
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):446-52
pubmed: 20585248
Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E994-E1002
pubmed: 27166282
Diabetes. 2008 Dec;57(12):3231-8
pubmed: 18776140
Biochem Biophys Res Commun. 2008 Nov 7;376(1):143-7
pubmed: 18765227
Nat Commun. 2014 Mar 19;5:3446
pubmed: 24647101
Sci STKE. 2000 Oct 10;2000(53):pe1
pubmed: 11752613
Elife. 2015 Dec 19;4:e12997
pubmed: 26687007
Cell Metab. 2010 Jun 9;11(6):554-65
pubmed: 20519126
Biochem J. 2008 Dec 15;416(3):375-85
pubmed: 18925875
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1572-7
pubmed: 14755054
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35
pubmed: 14985505
Cell. 2013 Jan 17;152(1-2):224-35
pubmed: 23332757
Nat Immunol. 2002 Dec;3(12):1129-34
pubmed: 12447370
Mol Cell Biol. 2008 Jan;28(2):551-63
pubmed: 17984223
Science. 2005 Feb 18;307(5712):1098-101
pubmed: 15718470
EMBO J. 1995 Aug 1;14(15):3731-40
pubmed: 7641692
Curr Biol. 2001 Apr 17;11(8):614-9
pubmed: 11369207
Free Radic Biol Med. 2009 May 1;46(9):1283-97
pubmed: 19245829
PLoS One. 2012;7(10):e46923
pubmed: 23056530
Science. 1986 Apr 4;232(4746):34-47
pubmed: 3513311
Cell Cycle. 2011 Jul 15;10(14):2305-16
pubmed: 21670596
Science. 2005 Oct 14;310(5746):314-7
pubmed: 16224023
Semin Cell Dev Biol. 2018 Nov;83:22-28
pubmed: 29486236
Exp Neurol. 2006 Mar;198(1):25-30
pubmed: 16126198
Lab Invest. 1986 Sep;55(3):363-71
pubmed: 3747450
Mol Cell Endocrinol. 2010 Mar 25;316(2):129-39
pubmed: 19723556
Science. 2016 Feb 12;351(6274):728-733
pubmed: 26912861
Clin Chem. 2006 Apr;52(4):760-4
pubmed: 16497937
Mol Cell. 2013 Feb 7;49(3):399-410
pubmed: 23395270
J Biol Chem. 2002 Aug 16;277(33):29626-33
pubmed: 12050154
Trends Biochem Sci. 2009 Dec;34(12):620-7
pubmed: 19875293
J Biol Chem. 2001 Oct 19;276(42):38388-93
pubmed: 11507097
Cell Metab. 2005 Jul;2(1):21-33
pubmed: 16054096
Free Radic Res. 2011 Jan;45(1):37-52
pubmed: 20942571
Brain Res Mol Brain Res. 2003 Jan 31;110(1):45-51
pubmed: 12573532
World Allergy Organ J. 2012 Jan;5(1):9-19
pubmed: 23268465
Clin Interv Aging. 2019 May 01;14:763-771
pubmed: 31118597