FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State.
colon cancer
drug resistance
fucosylation
glycosylation
pluripotency
stem cells
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
09
06
2020
revised:
20
08
2020
accepted:
01
09
2020
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
16
9
2020
Statut:
epublish
Résumé
Cancer stem cells (CSCs) are located in dedicated niches, where they remain inert to chemotherapeutic drugs and drive metastasis. Although plasticity in the CSC pool is well appreciated, the molecular mechanisms implicated in the regulation of cancer stemness are still elusive. Here, we define a fucosylation-dependent reprogramming of colon cancer cells towards a stem cell-like phenotype and function. De novo transcriptional activation of
Identifiants
pubmed: 32927726
pii: cancers12092580
doi: 10.3390/cancers12092580
pmc: PMC7565653
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Union (Marie-Curie European Training Network), GlyCoCan project
ID : 676421
Organisme : Cancer Center Amsterdam (CCA)
ID : 2003849
Organisme : European Research Council, Glycotreat project
ID : 339977
Organisme : Dutch Cancer Society (KWF)
ID : 2014-6779
Organisme : Dutch Cancer Society (KWF)
ID : 12420
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