Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future.
Hodgkin cells
Lamin A/C
Reed–Sternberg cells
TRF2
classical Hodgkin lymphoma
genetic instability
shelterin
telomere dysfunction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
12
08
2020
revised:
07
09
2020
accepted:
09
09
2020
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed-Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.
Identifiants
pubmed: 32927751
pii: ijms21186623
doi: 10.3390/ijms21186623
pmc: PMC7554683
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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