Role for ovarian hormones in purinoceptor-dependent natriuresis.

Animals Cell Line Dose-Response Relationship, Drug Epithelial Sodium Channels / genetics Estradiol / metabolism Female Gene Expression Regulation / drug effects Kidney Medulla / physiology Male Natriuresis / physiology Ovariectomy Ovary / physiology RNA, Messenger / genetics Rats Rats, Sprague-Dawley Receptors, Purinergic P2 / genetics Receptors, Purinergic P2Y2 / genetics Sex Factors Suramin / pharmacology Type C Phospholipases / genetics
Ovariectomy Purinoceptors Renal medulla Sodium excretion

Journal

Biology of sex differences
ISSN: 2042-6410
Titre abrégé: Biol Sex Differ
Pays: England
ID NLM: 101548963

Informations de publication

Date de publication:
14 09 2020
Historique:
received: 27 03 2020
accepted: 01 09 2020
entrez: 15 9 2020
pubmed: 16 9 2020
medline: 5 8 2021
Statut: epublish

Résumé

Premenopausal women have a lower risk of hypertension compared to age-matched men and postmenopausal women. P2Y To test our hypothesis, we determined (i) the effect of inhibiting medullary P2 receptors by suramin (750 μg/kg/min) on urinary Na Acute P2 inhibition attenuated urinary Na These data suggest that ovary-intact females have enhanced P2Y

Sections du résumé

BACKGROUND
Premenopausal women have a lower risk of hypertension compared to age-matched men and postmenopausal women. P2Y
METHODS
To test our hypothesis, we determined (i) the effect of inhibiting medullary P2 receptors by suramin (750 μg/kg/min) on urinary Na
RESULTS
Acute P2 inhibition attenuated urinary Na
CONCLUSION
These data suggest that ovary-intact females have enhanced P2Y

Identifiants

DOI: 10.1186/s13293-020-00329-0 PMID: 32928299 PMC: PMC7490965
pubmed: 32928299
doi: 10.1186/s13293-020-00329-0
pii: 10.1186/s13293-020-00329-0
pmc: PMC7490965
doi:

Substances chimiques

Epithelial Sodium Channels 0
RNA, Messenger 0
Receptors, Purinergic P2 0
Receptors, Purinergic P2Y2 0
purinoceptor P2Y4 0
Estradiol 4TI98Z838E
Suramin 6032D45BEM
Type C Phospholipases EC 3.1.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

52

Subventions

Organisme : NHLBI NIH HHS
ID : K99 HL144817
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL069999
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL136267
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK119413
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK044628
Pays : United States

Références

J Am Soc Nephrol. 2017 Dec;28(12):3504-3517
pubmed: 28774999
Clin Sci (Lond). 2013 Oct;125(7):311-8
pubmed: 23746374
J Biol Chem. 2008 Dec 26;283(52):36599-607
pubmed: 18981175
Nat Rev Nephrol. 2018 Mar;14(3):151-164
pubmed: 29355169
Hypertension. 1996 Oct;28(4):576-82
pubmed: 8843881
Biol Sex Differ. 2019 Jan 11;10(1):4
pubmed: 30635056
Transcr Open Access. 2015 Dec;3(2):
pubmed: 26949719
Curr Opin Nephrol Hypertens. 2019 Jan;28(1):1-9
pubmed: 30320621
Am J Physiol Renal Physiol. 2014 Jul 1;307(1):F33-40
pubmed: 24872316
Mol Endocrinol. 2005 Apr;19(4):833-42
pubmed: 15695368
Muscle Nerve. 2017 Jan;55(1):116-121
pubmed: 27220808
FASEB J. 2010 Jun;24(6):2056-65
pubmed: 20097874
Hypertension. 2016 Sep;68(3):e7-e46
pubmed: 27443572
Nucleic Acids Res. 2017 Jan 4;45(D1):D723-D729
pubmed: 27899570
Purinergic Signal. 2017 Mar;13(1):105-117
pubmed: 27817132
Ann Intern Med. 1994 Dec 15;121(12):936-41
pubmed: 7978718
Clin Exp Pharmacol Physiol. 2003 May-Jun;30(5-6):329-35
pubmed: 12859422
Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F260-7
pubmed: 27226106
Climacteric. 2013 Apr;16(2):205-13
pubmed: 23126249
Acta Physiol (Oxf). 2017 Nov;221(3):204-220
pubmed: 28544543
Physiol Rev. 2020 Jan 1;100(1):211-269
pubmed: 31437091
J Bone Miner Metab. 2018 Jul;36(4):488-497
pubmed: 28884379
J Menopausal Med. 2014 Apr;20(1):1-6
pubmed: 25371885
Curr Hypertens Rep. 2014 Jan;16(1):408
pubmed: 24343167
Maturitas. 2016 May;87:5-17
pubmed: 27013283
Am J Physiol Renal Physiol. 2015 Aug 15;309(4):F305-17
pubmed: 26062878
Am J Physiol Renal Physiol. 2000 Jan;278(1):F43-51
pubmed: 10644654
Acta Physiol (Oxf). 2015 Jan;213(1):232-41
pubmed: 25345692
Curr Opin Nephrol Hypertens. 2010 Jan;19(1):98-105
pubmed: 19996890
Purinergic Signal. 2011 Mar;7(1):73-83
pubmed: 21484099
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F361-F369
pubmed: 28468962
Am J Physiol Renal Physiol. 2011 Sep;301(3):F463-75
pubmed: 21715471
Compr Physiol. 2012 Oct;2(4):2393-442
pubmed: 23720252
Histochemistry. 1980;69(1):39-48
pubmed: 7440259
Biol Sex Differ. 2019 Jan 3;10(1):1
pubmed: 30606254
Neuroreport. 2012 Jun 20;23(9):530-4
pubmed: 22581043
Biol Sex Differ. 2013 Dec 10;4(1):21
pubmed: 24321563
J Med Chem. 2002 Sep 12;45(19):4057-93
pubmed: 12213051
FASEB J. 2007 Nov;21(13):3717-26
pubmed: 17575258
J Appl Physiol (1985). 2001 Oct;91(4):1893-901
pubmed: 11568177
J Am Heart Assoc. 2020 May 18;9(10):e015110
pubmed: 32390531
PLoS Biol. 2020 Jul 14;18(7):e3000411
pubmed: 32663221
Korean J Anesthesiol. 2018 Oct;71(5):353-360
pubmed: 30157585
Life Sci. 2019 Dec 15;239:117082
pubmed: 31756345
Neuropharmacology. 1997 Sep;36(9):1127-39
pubmed: 9364468
Int J Biol Sci. 2018 Jul 27;14(10):1268-1276
pubmed: 30123075
Am J Physiol Renal Physiol. 2011 Jul;301(1):F118-24
pubmed: 21490139
J Membr Biol. 2001 Sep 15;183(2):115-24
pubmed: 11562793

Auteurs

Eman Y Gohar (EY)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA. emangohar@uabmc.edu.
ORCID: 0000-0003-0988-6445

Malgorzata Kasztan (M)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.

Shali Zhang (S)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.

Edward W Inscho (EW)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.

David M Pollock (DM)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, 720 20th St S, Kaul 840, Birmingham, AL, 35233, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Role for ovarian hormones in...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Role for ovarian hormones in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Role for ovarian hormones in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Canaux sodium épithéliaux › Role for ovarian hormones in...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Role for ovarian hormones in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Role for ovarian hormones in...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Médulla rénale › Role for ovarian hormones in...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques des voies urinaires › Diurèse › Natriurèse › Role for ovarian hormones in...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie gynécologique › Ovariectomie › Role for ovarian hormones in...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Role for ovarian hormones in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Role for ovarian hormones in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Role for ovarian hormones in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Role for ovarian hormones in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Role for ovarian hormones in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Récepteurs purinergiques P2Y2 › Role for ovarian hormones in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Role for ovarian hormones in...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Naphtalènesulfonates › Suramine › Role for ovarian hormones in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphodiesterases › Phospholipases › Type C Phospholipases › Role for ovarian hormones in...