Genetics in Light of Transcriptional Adaptation.

Adaptation, Physiological Animals Gene Expression Regulation Models, Biological Plants RNA Stability RNA, Messenger / chemistry Transcription, Genetic
animal models gene expression genetic compensation genome engineering transcriptional adaptation

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
12 2020
Historique:
received: 01 06 2020
revised: 04 08 2020
accepted: 14 08 2020
pubmed: 16 9 2020
medline: 3 7 2021
entrez: 15 9 2020
Statut: ppublish

Résumé

Genetics has recently benefited from the genome engineering revolution: genes can be knocked out, knocked down, or activated more easily than ever before. This range of genetic manipulations has also provided a range of outcomes, sometimes contradictory. But how much interesting biology hides within these discrepancies? Recent studies have shown that genetic compensation can be activated by some gene perturbations and not others, hinting that this phenomenon might skew our understanding of the genotype-phenotype relationship. We review the main findings regarding transcriptional adaptation, a newly discovered form of genetic compensation, and discuss their possible implications for establishing and analyzing animal and plant models to study gene function. We also touch upon how this new knowledge could benefit our understanding of disease-causing mutations and help explain cases of low penetrance or variable expressivity in human genetics.

Identifiants

DOI: 10.1016/j.tig.2020.08.008 PMID: 32928563 PMC: PMC7612536
pubmed: 32928563
pii: S0168-9525(20)30208-0
doi: 10.1016/j.tig.2020.08.008
pmc: PMC7612536
mid: EMS143943
pii:
doi:

Substances chimiques

RNA, Messenger 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

926-935

Subventions

Organisme : European Research Council
ID : 694455
Pays : International

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Zacharias Kontarakis (Z)

Genome Engineering and Measurement Laboratory, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland; Functional Genomics Center Zurich of ETH Zurich/University of Zurich, Zurich, Switzerland.. Electronic address: zkontarakis@ethz.ch.

Didier Y R Stainier (DYR)

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. Electronic address: didier.stainier@mpi-bn.mpg.de.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Eucaryotes › Animaux › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Eucaryotes › Plantes › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité de l'ARN › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Genetics in Light of Transcriptional Adaptation.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Genetics in Light of Transcriptional Adaptation.